New and Simple Approach for Preventing Postoperative Peritoneal Adhesions: Do not Touch the Peritoneum without Viscous Liquid—A Multivariate Analysis

Ayşan, Erhan; Bektaş, Hasan; Ersöz, Feyzullah; Sarı, Serkan; Kaygusuz, Arslan; Huq, Gülben Erdem

doi:10.1155/2012/368924

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Instead, most recent research has focused on short-term tissue engineering scaffolds and the utilization of PGA as a filler material coupled with other degradable polymer networks. PGA is often fabricated into a mesh network and has been used as a scaffold for bone, [27][28][29][30] cartilage, [31][32][33] tendon, 34,35 tooth, 36 vaginal, 37 intestinal, 38 lymphatic, 39 and spinal regeneration. 40 Although there has been research conducted into a wide range of applications, there exists significant issues with PGA.…”

Section: Polyglycolidementioning

confidence: 99%

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Biomedical applications of biodegradable polymers

Ulery

Nair

Laurencin

2011

J Polym Sci B Polym Phys

1,861

1,279

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Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are wide ranging with degradable polymers being used clinically as surgical sutures and implants. In order to fit functional demand, materials with desired physical, chemical, biological, biomechanical and degradation properties must be selected. Fortunately, a wide range of natural and synthetic degradable polymers has been investigated for biomedical applications with novel materials constantly being developed to meet new challenges. This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.

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Section: Polyglycolidementioning

confidence: 99%

“…Although glycolic acid is bioresorbable by cells via the citric acid cycle, 41 high level of glycolic acid have been linked to a strong, undesired inflammatory response. [42][43][44] In addition, PGA has mechanically failed as a biomaterial when used to facilitate colonic anastomosis formation 38 and prevent intrapericardial adhesions. 45…”

Section: Polyglycolidementioning

confidence: 99%

Biomedical applications of biodegradable polymers

Ulery

Nair

Laurencin

2011

J Polym Sci B Polym Phys

1,861

1,279

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“…It has been shown that the addition of phospholipids that facilitate intestinal gliding after surgery can reduce the formation of PPA by 30% [ 19 – 21 ]. If viscous fluids are administered, particularly before mechanical manipulation, adhesion formation can be reduced, possibly as a result of a reduction in mechanical trauma [ 22 , 23 ]. Surfactant was also applied before applying the uterine horn adhesion procedure in the current experiment.…”

Section: Discussionmentioning

confidence: 99%

What is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study

PALA,

KULOĞLU,

ATILGAN

et al. 2023

Turkish Journal of Medical Sciences

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Background/Aim Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods Twenty-one Wistar albino rats were randomly divided into 3 groups (G1–G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, 2 mL of isotonic saline was administered intraperitoneally, and the abdomen was closed; and G3 (n = 7): treatment group. The abdomen was opened, a 2-cm linear incision was made over the right uterine horn, 2 mL (70 mg/kg) of surfactant was administered intraperitoneally, and the abdomen was closed. After 15 days, the rats were euthanized, the abdomens were reopened, and adhesion scoring was performed. After the right uterine horns were removed and fixed with 10% formalin, appropriate sections were taken from the traumatized tissue, stained with Masson’s trichrome, and fibrosis and inflammation scoring were performed. Results The adhesion area and intensity were significantly higher in G2 than in G1 and G3 (p = 0.001) and were similar in G1 and G3 (p = 0.165). While fibrosis and inflammation were significantly higher in G2 than in G1 and G3 (p = 0.001), there was no difference between G1 and G3 (p = 0.5). Conclusion Intraperitoneal surfactant administration at a dose of 70 mg/kg was found to be effective in preventing intraabdominal adhesion formation in a rat uterine horn model.

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“…Poly(lactic‐co‐glycolic acid) (PLGA) hollow fiber membranes prepared using the wet phase inversion method were used in nerve tract guidance conduits . Poly(glycolic acid) (PGA) is a material that has been successfully used in various applications including bone, cartilage, tooth, tendon, intestinal, vaginal, and spinal regeneration …”

Section: Synthetic Biomaterials To Modulate Stem Cellsmentioning

confidence: 99%

Engineering Concepts in Stem Cell Research

Narayanan

Mishra

Singh

et al. 2017

Biotechnology Journal

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The field of regenerative medicine integrates advancements made in stem cells, molecular biology, engineering, and clinical methodologies. Stem cells serve as a fundamental ingredient for therapeutic application in regenerative medicine. Apart from stem cells, engineering concepts have equally contributed to the success of stem cell based applications in improving human health. The purpose of various engineering methodologies is to develop regenerative and preventive medicine to combat various diseases and deformities. Explosion of stem cell discoveries and their implementation in clinical setting warrants new engineering concepts and new biomaterials. Biomaterials, microfluidics, and nanotechnology are the major engineering concepts used for the implementation of stem cells in regenerative medicine. Many of these engineering technologies target the specific niche of the cell for better functional capability. Controlling the niche is the key for various developmental activities leading to organogenesis and tissue homeostasis. Biomimetic understanding not only helped to improve the design of the matrices or scaffolds by incorporating suitable biological and physical components, but also ultimately aided adoption of designs that helped these materials/devices have better function. Adoption of engineering concepts in stem cell research improved overall achievement, however, several important issues such as long-term effects with respect to systems biology needs to be addressed. Here, in this review the authors will highlight some interesting breakthroughs in stem cell biology that use engineering methodologies.

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New and Simple Approach for Preventing Postoperative Peritoneal Adhesions: Do not Touch the Peritoneum without Viscous Liquid—A Multivariate Analysis

Cited by 7 publications

References 11 publications

Biomedical applications of biodegradable polymers

Biomedical applications of biodegradable polymers

What is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study

Engineering Concepts in Stem Cell Research

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