New and Simple Methylene Blue Colorimetric Assay for Glycyrrhizin in Pharmaceuticals

Habib, Ahmed; El–Sebakhy, Nadia A.; Kadry, Hossameldin

doi:10.1002/jps.2600681007

Cited by 10 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saitoh et al (1976) isolated new isoflavonoids and chalcones from the fraction FM 100, which could Scarlat et al, 1985 contribute to the anti-ulcer activity of liquorice. Simple derivatives of glycyrrhetinic acid (the genin of glycyrrhizinic acid) such as carbenoxolone (an ester derivative) and deglycyrrhizinized liquorice (DGL), have been used extensively in gastric ulcer treatment (Habib et al, 1979;Bennett et al, 1980). Carbenoxolone derives from the hydrolysis of glycyrrhizinic acid after its extraction from liquorice root.…”

Section: Liquoricementioning

confidence: 99%

The plant kingdom as a source of anti-ulcer remedies

2000

View full text Add to dashboard Cite

Section: Liquoricementioning

confidence: 99%

The plant kingdom as a source of anti-ulcer remedies

2000

View full text Add to dashboard Cite

“…Carbenoxolone and deglycyrrhiziniclicorice (DGL) is used for the treatment of ulcer, and these are the major component of the glycyrrhizinic acid while aspirin and cimetidine also damage the mucosa. 105 Silybum marianum. Silymarin containing a mixture of flavonolignans, derived from the extract of Silybum marianum, is most beneficial for the peptic ulcer disease.…”

Section: Dna Damage and Other Mechanismsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytotherapeutic modalities for the management ofHelicobacter pyloriassociated peptic ulcer

et al. 2020

View full text Add to dashboard Cite

Due to an imbalance between aggressive factors known as hydrochloric acid (HCl), pepsin, leukotrienes, refluxed bile, defensive factors and reactive oxygen species, the peptic ulcer is formed in the stomach and duodenum which mostly include the function of prostaglandins, mucus bicarbonate barrier, enzymatic antioxidants, and some growth factors. H. pylori infection remained one of the considerable causes of peptic ulcer as it caused hypochlorhydria and struck off the defense mechanism of the stomach. The nonsteroidal anti-inflammatory drugs (NSAIDs) and stress are the most prevailing causes of peptic ulcer disease. Lack of physical exercise, little rest and due to poor leisure cause the peptic ulcer disease. Candies, chocolate, coffee, cigarettes, stress, and alcohol are the cause of peptic ulceration and suppression of acid in the stomach due to the utilization of antacid medication. Most of the ancient medical practices in the traditional alternative medicinal system include Unani, Ayurveda, Siddha, Homeopathy, Naturopathy, Chinese customary medicine, African conventional medicine, and Native American medicine. Without a hostile effect, the rate of curing the disease is the significance of natural products research. Peptic ulcer disease is the widespread nature of peptic ulcer in all class of population, which mostly may be due to rapidly changing the food habits and stress, causing the imbalance between gastric offensive and defensive factors. Curcuma longa is the most effective plant for the cure of peptic ulcer. Curcuma longa has anti-inflammatory and antioxidant activity. Curcuma longa remarkably reduces the level of inflammatory mediator (IL1) and (TNF) which was increased during the formation of an ulcer. In the rhizome of Curcuma longa, yellow pigment is present and widely used for the treatment of ulcer and decrease the inflammatory response. Symptoms include abdominal pain after taking a meal, nausea, vomiting, Anorexia and lose weight.

show abstract

“…Two individual zones were detected and identified using reference samples. Glycyrrhizin was determined in callus samples by a colorimetric method [15].…”

mentioning

confidence: 99%