2012
DOI: 10.1038/ja.2012.102
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New antimicrobial compounds from a marine-derived Bacillus sp.

Abstract: In the course of our ongoing research for antimicrobial agents, we isolated five new compounds, three 24-membered macrolactones, macrolactins X-Z (1-3) and two hydroxy unsaturated fatty acids, linieodolides A (5) and B (6), together with a known metabolite, macrolactinic acid (4), from the culture broth of a marine Bacillus sp. The structures of these metabolites were determined on the basis of their spectroscopic data interpretation. Their absolute configurations were addressed by modified Mosher's method and… Show more

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Cited by 23 publications
(6 citation statements)
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“…These complex FAs are generally hydroxy, amino, and epoxy FAs ( Figure 1 ). β-hydroxy FAs or β-amino FAs, regardless of their saturation or branched structure, are linked to polypeptides and form surfactant and antimicrobial agents ( Ongena and Jacques, 2008 ; Baindara et al, 2013 ; Mondol et al, 2013 ; Romano et al, 2013 ). Epoxy FAs, which consist of FAs with one or two epoxy group(s), can be produced by Bacillus genus species, and some possess antimicrobial properties ( Celik et al, 2005 ; Hou, 2008 ).…”
Section: Nature and Synthesis Of The Main Fas In The Bacillmentioning
confidence: 99%
“…These complex FAs are generally hydroxy, amino, and epoxy FAs ( Figure 1 ). β-hydroxy FAs or β-amino FAs, regardless of their saturation or branched structure, are linked to polypeptides and form surfactant and antimicrobial agents ( Ongena and Jacques, 2008 ; Baindara et al, 2013 ; Mondol et al, 2013 ; Romano et al, 2013 ). Epoxy FAs, which consist of FAs with one or two epoxy group(s), can be produced by Bacillus genus species, and some possess antimicrobial properties ( Celik et al, 2005 ; Hou, 2008 ).…”
Section: Nature and Synthesis Of The Main Fas In The Bacillmentioning
confidence: 99%
“…09ID194 cultured in modified Bennett’s broth medium, yielded six new unsaturated hydroxy fatty acids, named ieodomycins A–D ( 53 – 56 ) [34] and linieodolides A and B ( 57 and 58 ) [67] (Figure 15). The producing strain was isolated from a sediment sample collected from Ieodo, Republic of Korea’s southern reef.…”
Section: Bioactive Compoundsmentioning
confidence: 99%
“…09ID194 [67,83,84]. Interestingly, these compounds were produced by this strain only in low salinity culture medium (12 g/L) but not in high salinity culture medium (32 g/L).…”
Section: Bioactive Compoundsmentioning
confidence: 99%
“…This unusual structure provides researchers with the exciting opportunity of exploring various chemical modifications of the compound with the aim of developing of potentially more efficient antimicrobial agents [ 61 ]. The unsaturated fatty acids, linieodolides A ( 91 ) and B ( 92 ), were isolated from the culture broth of a marine Bacillus and the mechanism of their antimicrobial activity was proposed through the inhibition of bacterial fatty acid synthesis [ 62 ]. Two highly acetylated steroids, dysiroid A ( 93 ) and dysiroid B ( 94 ), were isolated from the marine sponge, Dysidea sp.…”
Section: Lipidsmentioning
confidence: 99%
“…The hydroxy group at C-15 in macrolactone ring increases the antimicrobial activity of macrolactins, whereas introduction of carbonyl group at C-15 decreases antimicrobial activity. The number of ring members and the presence of a hydroxy group at C-7 and C-9 position have no effect on the antibacterial activity [ 62 ].…”
Section: Polyketidesmentioning
confidence: 99%