New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Abstract

The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approach for the fast development of new electronic biosensing systems, linking a custom-designed front-end with a multipurpose system. We envision an open tool to help designers to focus on the target molecule and related detection method instead of designing each time a dedicated electronic device. The architecture of the proposed system is based on a modular approach, where only the front-end and the software need to be custom redesigned according to the application. Considering current research and applying a rigorous definition of the technical requirements, the core of the system is designed to fit the highest number of biosensing methods. The flexibility of this approach is successfully demonstrated with three different types of biosensors, i.e., amperometric, ion-sensitive, and memristive.

Continuous monitoring of propofol in human serum with fouling compensation by support vector classifier

“…In this work, chemicals, setup, and sensor (Section 3.1) are defined leveraging of previous works that had been proven to be suitable for the monitoring of anaesthetics (Stradolini et al, 2018a;Tuoheti et al, 2020). Section 3.2 describes the procedure for acquiring the samples, which resembles the real scenario of the target application.…”

Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum With Machine Learning

“…In addition to the sensor, a system allowing the monitoring of anaesthetics must include a potentiostat, i.e. the set of electronic components required to drive and read the electrochemical sensor [23]. Several circuits have been proposed for this purpose, but without considering long time detection of propofol [24], [25].…”

Printed Electrochemical Biosensors: Opportunities and Metrological Challenges

“…In diagnostics, the possibility to enable the reliable detection of very low concentrations of pathology-related biomarkers, with reduced time and costs with respect to actual biochemical and molecular assays, could bring a revolution in the early diagnosis of pathologies like cancer, cardiac or neurodegenerative diseases [7,8]. Finally, the possibility to integrate those biosensors in standalone platforms (e.g., wearable, point-of-care), usable even by non-experts at home, could provide a powerful contribution to eHealth and telemedicine [9][10][11].…”