New approach to detecting counterfeit drugs in tablets by DART mass spectrometry

Chernetsova, Elena S.; Бочков, П. О.; Zatonskii, G. V.; Абрамович, Р. А.

doi:10.1007/s11094-011-0622-y

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…Moreover, about 82% of the bags contained medicines that in spite of being sold to pregnant women are contraindicated in pregnancy. Other examples on the application of DART MS to the screening for falsied drugs have been reported by Helmy et al (etoricoxib), 55 Samms et al (alprazolam), 11 Chernetsova et al (glycin, nootropyl, anaprilin, mexidol, and biseptol), 56 and Moffat et al (tadalal). 57 In forensic investigations of falsied pharmaceuticals requiring identication and identity validation of unknown components, the use of multiple complementary analytical methods is oen necessary.…”

Section: Plasma and Solid-liquid Extraction-based Techniquesmentioning

confidence: 98%

Ambient mass spectrometry technologies for the detection of falsified drugs

et al. 2014

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Increased globalization of the pharmaceutical market has facilitated the unobstructed and fast spread of poor-quality medicines. Poor-quality medicines include spurious/falsely-labeled/falsified/counterfeit drugs (those that are deliberately and fraudulently mislabeled with respect to content and/or origin), substandard drugs (legitimate drugs that do not meet their quality specifications), and degraded medicines (good quality pharmaceuticals that suffered from deterioration caused by improper storage or distribution). Consumption of poor-quality pharmaceuticals is likely to increase morbidity and mortality. Moreover, poor-quality drugs can also contribute to the development of resistance to anti-infective medicines and decrease the quality of health care received by patients. To assess the true prevalence of poor quality drugs, tiered technology approaches enabling the testing of drug samples collected at points of sale are required, thus ensuring public health standards. High throughput and high resolution ambient mass spectrometry techniques allow investigation of pharmaceuticals with minimal or no sample preparation, thus possessing capabilities to survey a large number of drug samples for their authenticity.

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Section: Plasma and Solid-liquid Extraction-based Techniquesmentioning

confidence: 98%

Ambient mass spectrometry technologies for the detection of falsified drugs

et al. 2014

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“…Areas of interest for the forensic drug applications of DART have included screening for THC (tetrahydrocannabinol) or its derivatives, synthetic cannabinoids, and cannabimimetics (Blackledge, ; Musah et al, ,; Takahashi et al, ; Duvivier et al, ; Jacobs & Steiner, ; Lesiak et al, ); detecting adulterations and contaminants in drugs (Fernández et al, ; Newton et al, ,; Nyadong et al, ; Chernetsova et al, ; Samms et al, ; Zhou et al, ; Vaclavik, Krynitsky, & Rader, ); determining the nature or amount of the active ingredient in various known drugs or unknown pharmaceutical samples (Cody, Laramee, & Durst, ; Ropero‐Miller et al, ; Howlett & Steiner, ; Likar et al, ; Lesiak et al, , ; Easter & Steiner, ; Musah et al, ; Kuki et al, ); identifying synthetic precursors to drugs of abuse (Steiner, ); and detecting drug residues on surfaces, in fingerprints, or in liquid matrices (Cody, Laramee, & Durst, ; Blackledge, ; Bennett & Steiner, ; Grange & Sovocool, ; Lim et al, ).…”

Section: Drugs Of Abuse Seized Drugs and Pharmaceuticalsmentioning

confidence: 99%

Direct analysis in real time—Mass spectrometry (DART‐MS) in forensic and security applications

Pavlovich

Musselman²,

Hall

2016

Mass Spectrometry Reviews

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Over the last decade, direct analysis in real time (DART) has emerged as a viable method for fast, easy, and reliable "ambient ionization" for forensic analysis. The ability of DART to generate ions from chemicals that might be present at the scene of a criminal activity, whether they are in the gas, liquid, or solid phase, with limited sample preparation has made the technology a useful analytical tool in numerous forensic applications. This review paper summarizes many of those applications, ranging from the analysis of trace evidence to security applications, with a focus on providing the forensic scientist with a resource for developing their own applications. The most common uses for DART in forensics are in studying seized drugs, drugs of abuse and their metabolites, bulk and detonated explosives, toxic chemicals, chemical warfare agents, inks and dyes, and commercial plant and animal products that have been adulterated for economic gain. This review is meant to complement recent reviews that have described the fundamentals of the ionization mechanism and the general use of DART. We describe a wide range of forensic applications beyond the field of analyzing drugs of abuse, which dominates the literature, including common experimental and data analysis methods. © 2016 Wiley Periodicals, Inc. Mass Spec Rev 37:171-187, 2018.

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“…The traditional GC/MS method combined with preliminary derivatization has been employed for analysis of active substances and impurities in pharmaceutical substances. However, the possibilities of using DART mass spectrometry 206,207 and DESI 208 for the same purposes have also been investigated. On the basis of ESI-MS, a highly sensitive method has been developed that allows quantitative determination of antiarrhythmic drugs in blood plasma without preliminary chromatographic separation.…”

Section: Pharmacology Drugs and Metabolitesmentioning

confidence: 99%

Mass Spectrometry in Russia

Заикин

Сысоев

2013

Eur J Mass Spectrom (Chichester)

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The present review covers the main research in the area of mass spectrometry from the 1990s which was about the same time as the Russian Federation emerged from the collapse of the Soviet Union (USSR). It consists of two main parts-application of mass spectrometry to chemistry and related fields and creation and development of mass spectrometric technique. Both traditional and comparatively new mass spectrometric methods were used to solve various problems in organic chemistry (reactivity of gas-phase ions, structure elucidation and problems of identification, quantitative and trace analysis, differentiation of stereoisomers, derivatization approaches etc.), biochemistry (proteomics and peptidomics, lipidomics), medical chemistry (mainly the search of biomarkers, pharmacology, doping control), environmental, petrochemistry, polymer chemistry, inorganic and physical chemistry, determination of natural isotope ratio etc. Although a lot of talented mass spectrometrists left Russia and moved abroad after the collapse of the Soviet Union, the vitality of the mass spectral community proved to be rather high, which allowed the continuation of new developments in the field of mass spectrometric instrumentation. They are devoted to improvements in traditional magnetic sector mass spectrometers and the development of new ion source types, to analysis and modification of quadrupole, time-of-flight (ToF) and ion cyclotron resonance (ICR) analyzers. The most important achievements are due to the creation of multi-reflecting ToF mass analyzers. Special attention was paid to the construction of compact mass spectrometers, particularly for space exploration, of combined instruments, such as ion mobility spectrometer/mass spectrometer and accelerating mass spectrometers. The comparatively young Russian Mass Spectrometry Society is working hard to consolidate the mass spectrometrists from Russia and foreign countries, to train young professionals on new appliances and regularly holds conferences on mass spectrometry. For ten years, a special journal Mass-spektrometria has published papers on all disciplines of mass spectrometry.

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New approach to detecting counterfeit drugs in tablets by DART mass spectrometry

Cited by 16 publications

References 5 publications

Ambient mass spectrometry technologies for the detection of falsified drugs

Ambient mass spectrometry technologies for the detection of falsified drugs

Direct analysis in real time—Mass spectrometry (DART‐MS) in forensic and security applications

Mass Spectrometry in Russia

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