2023
DOI: 10.1007/7854_2022_411
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New Approaches for Alcohol Use Disorder Treatment via Memory Retrieval and Reconsolidation Manipulations

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Cited by 2 publications
(5 citation statements)
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“…Importantly, we found increased ERK1/2 activation in the amygdala, but not in the mPFC, NAc, or OFC, which are also known to be key regions for drug memory reconsolidation [16,19,35,46,58,[70][71][72][73][74]. These results extend our previous findings of increased mTORC1 activation following alcohol memory retrieval, using two different retrieval methods [19].…”
Section: Erk1/2 Is Crucial For Alcohol Memory Reconsolidationsupporting
confidence: 87%
“…Importantly, we found increased ERK1/2 activation in the amygdala, but not in the mPFC, NAc, or OFC, which are also known to be key regions for drug memory reconsolidation [16,19,35,46,58,[70][71][72][73][74]. These results extend our previous findings of increased mTORC1 activation following alcohol memory retrieval, using two different retrieval methods [19].…”
Section: Erk1/2 Is Crucial For Alcohol Memory Reconsolidationsupporting
confidence: 87%
“…Although the assessment of manipulations on memory reconsolidation typically requires post-retrieval treatments 10,11 , we chose here to inject SAFit2 16 hours before the memory-retrieval session, as this inhibitor was shown to exert anxiolytic effects 16 hours post its systemic administration 56,65,71 . Interestingly, in a previous study that was conducted solely on male mice, SAFit2 was shown to reduce the reinstatement of alcohol-seeking behavior in alcohol-CPP, when administered at a lower dose than the dose used in the current study two hours before the alcohol-primed reinstatement test, and in the absence of a retrieval procedure 84 .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the difference in the species possibly contributed to the discrepancy in the effects of each retrieval method on Fkbp5 expression. Additionally, the memory-formation phase in the CPP procedure includes only four injections of alcohol, whereas, during the IA2BC training, the rats are given access to alcohol bottles for several weeks, allowing the formation of memories that are stronger and older at the time of the retrieval 11,87 .…”
Section: Retrieval Of Alcohol Memories Via An Odor-taste Cue Does Not...mentioning
confidence: 99%
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