New approaches to extraction techniques in determination of 4,4′-methylenebis(2-chloroaniline) in air and water solutions

Buszewski, Bogusław; Olszowy, Pawel; Szultka, Małgorzata; Jeżewska, Anna

doi:10.1016/j.talanta.2012.01.057

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…W celu zwiększenia trwałości analitu i podniesienia czułości oznaczenia chromatograficznego zastosowano chlorek 3,5-dinitrobenzoilu jako substancję derywatyzującą, która według danych literaturowych [18][19][20][21][22] reaguje z aminami, dając trwałą pochodną. W trakcie badań dobrano ilość substancji derywatyzującej oraz warunki przeprowadzenia amin w substancje pochodne.…”

Section: Wynikiunclassified

A new method for determination of toluene-2,4-diamine and toluene-2,6-diamine in workplace air

Kowalska¹,

Jeżewska²

2017

Med Pr

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StreszczenieWstęp: Toluenodiaminy są substancjami szkodliwymi. Tolueno-2,4-diamina została sklasyfikowana według rozporządze-nia Parlamentu Europejskiego i Rady (Wspólnoty Europejskiej -WE) nr 1272/2008 jako substancja rakotwórcza kategorii 1B, natomiast tolueno-2,6-diamina jako substancja mutagenna kategorii 2. Substancje te wchłaniają się do organizmu człowieka głównie przez układ oddechowy i skórę. Tolueno-2,4-diamina i tolueno-2,6-diamina występują w środowisku pracy w Polsce. Celem badania było opracowanie i walidacja metody oznaczania tolueno-2,4-diaminy i tolueno-2,6-diaminy, która umożliwi jednoczesne oznaczanie stężeń tych substancji w powietrzu na stanowiskach pracy metodą dozymetrii indywidualnej. Materiał i metody: W artykule przedstawiono metodę oznaczania tolueno-2,4-diaminy i tolueno-2,6-diaminy w powietrzu na stanowiskach pracy z zastosowaniem wysokosprawnej chromatografii cieczowej (high-pressure liquid chromatography -HPLC) z detektorem diodowym. Metoda polega na: przepuszczeniu badanego powietrza zawierającego tolueno-2,4-diaminę i tolueno-2,6--diaminę przez filtr z włókna szklanego z naniesionym kwasem siarkowym(VI), wymyciu osadzonych na filtrze substancji wodą i roztworem wodorotlenku sodu, przeprowadzeniu ekstrakcji ciecz-ciecz z zastosowaniem toluenu, reakcji z chlorkiem 3,5-dinitrobenzoilu oraz wymiany rozpuszczalnika na acetonitryl. Tak uzyskany rozwór poddano analizie chromatograficznej. Wyniki: Metoda umożliwia oznaczanie tolueno-2,4-diaminy i tolueno-2,6-diaminy w obecności innych substancji. W badanym zakresie stężeń (2,88-57,6 μg/ml) uzyskana krzywa wzorcowa jest liniowa. W ustalonych warunkach oznaczania granica wykrywalności (limit of detection -LOD) wynosi: 51,36 ng/ml dla tolueno-2,4-diaminy i 52,93 ng/ml dla tolueno-2,6-diaminy. Wnioski: Opracowana metoda umożliwia oznaczanie tolueno-2,4-diaminy i tolueno-2,6-diaminy w powietrzu na stanowiskach pracy w zakresie stężeń 0,004-0,08 mg/m 3 dla próbki powietrza 720 l. Med. Pr. 2017;68(4):497-505Słowa kluczowe: stanowisko pracy, czynnik rakotwórczy, analiza powietrza, diaminotoluen, chlorek dinitrobenzoilu, HPLC AbstractBackground: Toluenediamines are harmful substances. Toluene-2,4-diamine has been assigned to Carcinogen 1B hazard class, pursuant to Regulation (European Community -EC) No. 1272/2008 of the European Parliament and of the Council, and toluene-2,6-diamine to Mutagen 2 hazard class. The main routes of exposure to toluene-2,4-diamine and toluene-2,6-diamine are via the respiratory tract and the skin. Toluene-2,4-diamine and toluene-2,6-diamine occur in the work environment in Poland. The aim of this study was to develop and validate a method for the determination of toluene-2,4-diamine and toluene-2,6-diamine that allows the simultaneous determination of their concentrations in the workplace air by personal sampling. Material and Methods: Determination of toluene-2,4-diamine and toluene-2,6-diamine derivatives in acetonitrile were carried out by means of liquid chromatography with a diode assay detector. The method invol...

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Section: Wynikiunclassified

A new method for determination of toluene-2,4-diamine and toluene-2,6-diamine in workplace air

Kowalska¹,

Jeżewska²

2017

Med Pr

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“…To overcome this limitation, the aliphatic amines are derivatized or tagged with some strongly absorbing chromophore [98]. Except the following traditional methods, some newly fluorescence/ultraviolet reagents, such as HTFA for chromium, H(FHD) for beryllium and lanthanide, DNBC for 4,4′-methylenebis (2-chloroaniline) [99], 1-NC for alcohol ethoxylate (Brij 56), and 1-hexadecanol [100], have been developed with in vial derivatization combined with DI or HS SPME and HPLC or LC analysis.…”

Section: Fluorescence/ultraviolet Derivatizationmentioning

confidence: 99%

“…Combination of derivatization with SPME has been utilized for air and particle matters sampling in the field [116,117,153] or in the laboratory work [102,109]. Commercial SPME fibers such as PDMS, PDMS/DVB, CW/DVB, and CW/TPR have been widely used for most applications [102,109,114,116,117,153], and also, novel nanoporous polymeric (polypyrrole and polythiophene, PPy/PTh) fiber coating were used [99].…”

Section: Air and Aerosolsmentioning

confidence: 99%

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Application of Solid-Phase Microextraction Combined with Derivatization for Polar Compound Sampling in Environmental Analysis

Yang¹,

Luan²

2016

Solid Phase Microextraction

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Solid-phase microextraction (SPME) is a solvent-free sample preparation technique using a fused-silica fiber coated with an appropriate stationary phase. Derivatization is often necessary to determine substances with poor chromatographic behavior, high reactivity, and/or volatility or thermal instability. SPME derivatization technique can be operated under different combined modes and may be influenced by factors such as sample matrix, SPME, derivatization, and desorption condition. Combined with derivatization, HS-SPME, DI-SPME, membrane-protected SPME, and in-tube SPME have been applied to the analysis of a vast amount of chemicals, i.e., aldehydes and acetone, amines, organic acids, phenolic compounds, pesticide, metal and organic metal species, and pharmaceutical and personal care products (PPCPs) in a wide range of environmental matrices, including air, water, soil, and sediment samples. This chapter reviews the mode and method development of the derivatization technique, the derivatization reagents, and reaction mechanism, as well as its applications in environmental analysis.

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“…Moreover, there is a strict limit for the *Corresponding author, e-mail: xschai@gmail.com Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 7/23/15 11:09 AM injection of a water based sample into most GC capillary columns because a significant amount of water vapor damages the columns and detectors, e.g., electron capture detector (ECD) and mass spectrometer (MS). To avoid this problem, organic solvent-extraction is a typical sample pretreatment procedure before GC testing (Tabrizi, 2007;Buszewski et al, 2012;Zhou et al, 2011), which is not only complicated and timeconsuming but it also introduces a significant error in the species quantification.…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of products of phenol hydrogenation in a supercritical water system using headspace gas chromatography

et al. 2015

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This paper reports a headspace analysis technique for the determination of products, i.e., cyclohexanone (CE) and cyclohexanol (CL), of phenol hydrogenation in a supercritical water reaction system (SWRS) with water removal by hydrate formation. An addition of anhydrous calcium chloride leads to water absorption resulting in crystal water; thus, the samples can be quantitatively measured without the influence of water. After achieving equilibrium at 150 • C and maintaining it for 5 min, the obtained results showed a relative standard deviation of less than 5.3 % and the recovery ranged from 93 % to 104 %. The presented method is simple and accurate for the analysis of CL, CE and phenol in samples from phenol conversion in SWRS.

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New approaches to extraction techniques in determination of 4,4′-methylenebis(2-chloroaniline) in air and water solutions

Cited by 12 publications

References 13 publications

A new method for determination of toluene-2,4-diamine and toluene-2,6-diamine in workplace air

A new method for determination of toluene-2,4-diamine and toluene-2,6-diamine in workplace air

Application of Solid-Phase Microextraction Combined with Derivatization for Polar Compound Sampling in Environmental Analysis

Rapid determination of products of phenol hydrogenation in a supercritical water system using headspace gas chromatography

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