2020
DOI: 10.33380/2305-2066-2020-9-1-13-17
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New approaches to Improving Bendamustine Microractor Synthesis

Abstract: Introduction. The chlorination reaction in the synthesis of the substance of bendamustine hydrochloride is a complex process. The presence of active adverse reactions makes scaling difficult.Aim. Improving the performance of the technology for producing bendamustine ethyl ester in a flow microreactor.Materials and methods. A series of experiments was carried out to carry out the chlorination stage in the synthesis of bendamustine hydrochloride in a flow microreactor with various concentrations in the initial r… Show more

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