New aspects on the preparation of [11C]acetate—a simple and fast approach via distillation

Mitterhauser, Markus; Wadsak, Wolfgang; Krcal, Andreas; Schmaljohann, Jörn; Bartosch, Ewald; Eidherr, Harald; Viernstein, Helmut; Kletter, Kurt

doi:10.1016/j.apradiso.2004.03.060

Cited by 19 publications

(11 citation statements)

References 7 publications

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“…Radiopharmaceutical preparation and imaging 67 Ga citrate was supplied by CIS Bio International (Gif-Sur-Yvette Cedex, France). 11 C-acetate was produced according to the previously described method (17). The radiochemical yield was about 9 GBq for each run (56%), and the specific activity was about 7.4 GBq/mmol.…”

Section: Patientsmentioning

confidence: 99%

Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Beheshti

Peck‐Radosavljevic³

et al. 2006

Liver International

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Section: Patientsmentioning

confidence: 99%

Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Beheshti

Peck‐Radosavljevic³

et al. 2006

Liver International

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“…[14] The chemical and radiochemical purities were both greater than 98%. The product was proved to be sterile by 24 h bacterial culture.…”

Section: Methodsmentioning

confidence: 95%

Application of Dual Phase Imaging of 11C-Acetate Positron Emission Tomography on Differential Diagnosis of Small Hepatic Lesions

Huo

Dang

et al. 2014

PLoS ONE

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ObjectivePreviously we observed that dual phase 11C-acetate positron emission tomography (AC-PET) could be employed for differential diagnosis of liver malignancies. In this study, we prospectively evaluated the effect of dual phase AC-PET on differential diagnosis of primary hepatic lesions of 1–3 cm in size.Methods33 patients having primary hepatic lesions with size of 1–3 cm in diameter undertook dual phase AC-PET scans. Procedure included an early upper-abdomen scan immediately after tracer injection and a conventional scan in 11–18 min. The standardized uptake value (SUV) was calculated for tumor (SUVT) and normal tissue (SUVB), from which 11C-acetate uptake ratio (as lesion against normal liver tissue, SUVT/SUVB) in early imaging (R1), conventional imaging (R2), and variance between R2 and R1 (ΔR) were derived. Diagnoses based on AC-PET data and histology were compared. Statistical analysis was performed with SPSS 19.0.Results20 patients were found to have HCC and 13 patients had benign tumors. Using ΔR>0 as criterion for malignancy, the accuracy and specificity were significantly increased comparing with conventional method. The area under ROC curve (AUC) for R1, R2, and ΔR were 0.417, 0.683 and 0.831 respectively. Differential diagnosis between well-differentiated HCCs and benign lesions of FNHs and hemangiomas achieved 100% correct. Strong positive correlation was also found between R1 and R2 in HCC (r2 = 0.55, P<0.001).ConclusionsDual phase AC-PET scan is a useful procedure for differential diagnosis of well-differentiated hepatocellular carcinoma and benign lesions. The dynamic changes of 11C-acetate uptake in dual phase imaging provided key information for final diagnosis.

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“…Synthesis was conducted under sterile conditions using an automated synthesis apparatus with [ 11 C]carbon dioxide as a substrate. [ 11 C]acetate was synthesized by reaction of methylmagnesium bromide with [ 11 C] carbon dioxide in tetrahydrofuran, followed by hydrolysis and isolation via distillation .…”

Section: Methodsmentioning

confidence: 99%

Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [¹¹C]acetate PET as a prognostic marker

et al. 2015

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New aspects on the preparation of [11C]acetate—a simple and fast approach via distillation

Cited by 19 publications

References 7 publications

Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Application of Dual Phase Imaging of 11C-Acetate Positron Emission Tomography on Differential Diagnosis of Small Hepatic Lesions

Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [¹¹C]acetate PET as a prognostic marker

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New aspects on the preparation of [11C]acetate—a simple and fast approach via distillation

Cited by 19 publications

References 7 publications

Comparison of 11C‐acetate positron emission tomography and 67Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Comparison of 11C‐acetate positron emission tomography and 67Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Application of Dual Phase Imaging of 11C-Acetate Positron Emission Tomography on Differential Diagnosis of Small Hepatic Lesions

Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [11C]acetate PET as a prognostic marker

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Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Comparison of ¹¹C‐acetate positron emission tomography and ⁶⁷Gallium citrate scintigraphy in patients with hepatocellular carcinoma

Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [¹¹C]acetate PET as a prognostic marker