New Benzenoids from the Roots of <i>Lindera aggregata</i>

Guo, Hao; Lin, Che; Hung, Hsin Yi; Wang, Sheng-Yang; Shieh, Po Chuen; Wu, Tian Shung

doi:10.1177/1934578x1501001229

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…In addition to the above-mentioned extensive components in L. aggregata , there are also several other rare components, including 2 benzenoids (13–14), a benzene-type glycoside (15), 3 lindera cyclopentenedione derivatives (16–18), 3 bi-linderone derivatives (19, 20a, 20b), a butenolide (21), 3 lignans (22–24), 10 phenolics (25–34) and a linderaspirone (35) ( 16 , 39 , 54 , 55 ). They also demonstrate good pharmacological activities, such as compound 21 has anti-tumor activity, and compounds 19 and 35 show good anti-diabetic properties due to their significant insulin resistance alleviation ( 55 – 57 ).…”

Section: Chemical Compoundsmentioning

confidence: 99%

“…LA-R extract is the primary natural source of alkaloids. Thirty-seven alkaloids (1-37) have been successfully identified from L. aggregata, including 15 aporphine alkaloids (1-15), 8 benzyl tetrahydroisoquinoline alkaloids (16)(17)(18)(19)(20)(21)(22)(23), 2 morphinan alkaloids (24,25), 5 bis-benzyl tetrahydroisoquinoline alkaloids (26)(27)(28)(29)(30), a β-carboline alkaloid (31) and 6 amides (32-37) (13,16,24,(36)(37)(38)(39)(40)(41)(42)(43). Their structures and molecular formulae are shown in Table 2 and Figure 3.…”

Section: Alkaloidsmentioning

confidence: 99%

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A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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Lindera aggregata (Sims) Kosterm. (L. aggregata), which belongs to the genus Lindera in the family Lauraceae, is widely distributed in Asia and the temperate, tropical regions of North America. Its roots and leaves have been used for thousands of years as traditional Chinese medicine and/or functional food. To further explore its underlying nutritional value, this review provided a comprehensive insight into chemical constituents and pharmacological effects on L. aggregata. The phytochemical investigation of different parts of L. aggregata led to the identification of up to 349 components belonging to sesquiterpenoids, alkaloids, flavonoids, essential oils, and other compounds. Among them, sesquiterpenoids, flavonoids, and alkaloids are assessed as representative active ingredients of L. aggregata. A wide variety of pharmacological effects of L. aggregata, such as anti-hyperlipidemic, anti-tumor, anti-inflammatory, analgesic, and anti-oxidant, have been proved in vitro and in vivo. In summary, this review aims to provide a scientific basis and reference for further research and utilization of L. aggregata and lay the foundation for developing functional foods with potential active ingredients for the prevention and management of related diseases.

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Section: Chemical Compoundsmentioning

confidence: 99%

Section: Alkaloidsmentioning

confidence: 99%

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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“…5. Ma et al (2015) managed to isolate two new benzenoids, identified as linderagatin A and B (100-101), together with three known lignans, rel-(2α,3β)-7-Omethylcedrusin (97), (-)-lyoniresinol (98), and evofolin B (99) from the roots part.…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological activities

Salleh¹

2020

BLACPMA

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The genus Lindera consists of approximately 100 species that are widely distributed in tropical and subtropical areas throughout the world. Most Lindera plants, particularly Lindera aggregata is a well-known traditional Chinese medicine that has important medicinal value and health benefits. Contemporary chemical and pharmacological studies have shown that L. aggregata are a source of structurally diverse molecules having pharmacological potential. In an effort to promote research on L. aggregata and develop therapeutic and pharmacological products, this review describes the structural diversity of its components and pharmacological and biological significance of L. aggregata. This review is based on a literature analysis of scientific journals from electronic sources, such as Science Direct, PubMed, Google Scholar, Scopus and Web of Science. Thus, with the growing interest in traditional medicine and botanical drugs worldwide, L. aggregata will increasingly capture chemists’ and pharmacologists’ attention because they produce diverse and structurally novel compounds having pharmacological significance.

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New prenyl flavanone and diarylbutanol from Uvaria siamensis stem bark and their α -glucosidase inhibitory activity

Nguyen,

Ngo,

Nguyen

et al. 2023

Natural Product Research

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New Benzenoids from the Roots of Lindera aggregata

Cited by 4 publications

References 32 publications

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological activities

New prenyl flavanone and diarylbutanol from Uvaria siamensis stem bark and their α -glucosidase inhibitory activity

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