New Benzophenones and Xanthones from <i>Cratoxylum sumatranum</i> ssp. <i>neriifolium</i> and Their Antibacterial and Antioxidant Activities

The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.

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“…The antibacterial assay was determined as recommended by Clinical and Laboratory Standards Institute. 34,35…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

et al. 2018

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“…Compound 2 was isolated as yellow crystals, with m/z 274.402 in the positive ion mode ESI-MS, the molecular matching with the xanthone molecular formula C 14 H 10 O 6 . [14] The phenolic nature was confirmed from the positive reaction with ferric chloride solution (5 % FeCl 3 in methanol). Typical bands were shown in short and long UV spectra at 206, 266, and 350 nm.…”

Section: Purification Of the Isolated Compoundsmentioning

confidence: 99%

A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities

AbdelRazek

Moussa

El‐Shanawany

et al. 2020

Chemistry & Biodiversity

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Human infections caused by microbial biofilm formation represent a growing major health threat. A new alkaloid, 3-amino-5-(3-hydroxybutan-2-yl)-4-methylphenol, was isolated from the corn grit culture of the endophytic isolate Penicillium citrinum-314 associated with Halocnemum strobilaceum, a halophyte growing in the Egyptian marshes. The new alkaloid was identified by 1D, 2D-NMR and HR-ESI-MS-MS and given the trivial name halociline. The antioxidant, antimicrobial and antibiofilm activities were recorded. Furthermore, another known compound, 1,3,6-trihydroxy-7-methoxy-9H-xanthen-9-one, was obtained in smaller amounts and revealed a non-microbicidal 100 % reduction in biofilm formation, with an MBIC value of 62.5 μg/mL (228 μM) against Pseudomonas aeruginosa (Ferm-BAM), a FRAP value of 447.941 � 37.876 mM/L as well as a marked safety profile against three cancer cell lines. Through in silico molecular docking study, in the binding sites of Pseudomonas enzymes, key ligand enzyme interactions were determined to support the in vitro results.

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“…5-O-methylisojacareubin; 2,4,6-trimethoxybenzophenone; 4-hydroxy-2,6dimethoxybenzophenone; and annulatomarin. 11 Amoebiasis is a common infection in the human digestive tract. The diseaseis caused by E. histolytica, which is a pathogenic species found on human colon tissues.…”

Section: Introductionmentioning

confidence: 99%

In vitro Anti-Amebic Activity of Cage Xanthones from Cratoxylum sumatranum Stem Bark Against Entamoeba histolytica

Wardana¹,

Sari²,

Adianti³

et al. 2020

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Background: Amoebiasis is caused by Entamoeba histolytica, which is a pathogenic species living on human colon tissues. The development of new drugs for anti-amebic are still very needed for clinical treatment. Objective: This aims to identify the compounds in Cratoxylum sumatranum for their anti-amoeba activity. Materials and Methods: In this study we used bioactivity-guided isolation and structural analysis to identified anti-amebic compounds from dichloromethane extract of Cratoxylum sumatranum stem bark. Their anti-amebic activity was determined by an in vitro cell-based assay against Entamoeba histolytica and an enzymatic assay on NAD kinase. Results: Two known compounds from the cage xanthone groups, namely cochinchinoxanthone (1) and cochinchinone D (2), were isolated. The structures of the cage xanthone compounds were established by extensive spectroscopic data analysis. Compound (1) showed the greatest level of anti-amebic activity both in cell-based and enzymatic assay, yielding IC 50 values of 4.57 and 12.17 µg/mL, respectively. In contrast, compound (2) yielded IC 50 values of 5.19 and 12.60 µg/mL, respectively. Conclusion: When considering the demonstrated anti-amebic activities, it becomes apparent that these compounds, isolated from Cratoxylum sumatranum stem bark, have the potential to be further developed into effective anti-amebic medicine against Entamoeba histolytica.

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New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities

Cited by 42 publications

References 40 publications

Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities

In vitro Anti-Amebic Activity of Cage Xanthones from Cratoxylum sumatranum Stem Bark Against Entamoeba histolytica

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