New binary and ternary platinum(II) formamidine complexes: Synthesis, characterization, structural studies and in-vitro antitumor activity

Soliman, Ahmed A.; Alajrawy, Othman I.; Attaby, Fawzy A.; Linert, Wolfgang

doi:10.1016/j.molstruc.2016.02.073

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…Electronic transition will be easier in compounds having lower ΔE (E LUMO – E HOMO ) and lower hardness value. [ 60 ] In addition, the low absolute values of the energy band gap (ΔE = E LUMO – E HOMO ) imply low kinetic stability and high chemical reactivity. [ 61 ] When we look at the hardness values and ΔE values in Table 2, complex 6 would be most active chemically because it has the lowest η (chemical hardness, Figure 9) and lowest ΔE value.…”

Section: Resultsmentioning

confidence: 99%

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

Rafikova

Binbay

Meri̇ç

et al. 2020

Applied Organom Chemis

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Four metal complexes, IL‐OPPh2‐Ru‐p‐cymene (3), IL‐OPPh2‐Ru‐benzene (4), IL‐OPPh2‐Ir‐Cp* (5), IL‐OPPh2‐Rh‐COD (6), have been evaluated for in vitro antioxidant activity such as 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and reducing power activity. Maximum scavenging activity (71.43%) was obtained with IL‐OPPh2‐Ru‐p‐cymene, whereas IL‐OPPh2‐Rh‐COD showed the highest reducing power ability. The complexes were also studied for their antimicrobial activity against three Gram‐positive and three Gram‐negative bacteria. In addition, DNA binding of the complexes was evaluated using calf thymus DNA. Both Ru(II) complexes exhibited good DNA‐binding activity while the other complexes did not have any activity. Furthermore, ab initio quantum calculations of four complexes were also carried out using density functional theory to better understand their chemical behaviors.

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Section: Resultsmentioning

confidence: 99%

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

Rafikova

Binbay

Meri̇ç

et al. 2020

Applied Organom Chemis

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“…In a previous paper, we published details on palladium(II) and platinum(II) complexes with formamidine ligands. 29,30 In the present work, we report the synthesis, characterization, DFT calculations, and antitumor activity of new ternary palladium(II) complexes with formamidine and pyrophosphate ligands.…”

Section: àmentioning

confidence: 99%

New dinuclear palladium(ii) complexes with formamidine and bridged pyrophosphate ligands

et al. 2016

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“…The second loss (61.46%) occurring in the temperature range of 380-490°C corresponds to the decomposition of quinoline based 1,3,5-tri-substituted pyrazole ligands, leaving behind metallic platinum as a residue. 39 These results suggest that the platinumĲII) complexes have high thermostability.…”

Section: Thermo-gravimetric Analysismentioning

confidence: 89%

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

et al. 2018

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Square planar mononuclear platinum(ii) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and KPtCl salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, H NMR,C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by brine shrimp lethality bioassay, antimicrobial study against five different pathogens, cellular level cytotoxicity against cells, and anti-proliferation assay. The binding constant, , values of the complexes were determined by DNA interaction studies. The gel electrophoresis assay was carried out to examine the effect of the complexes on the DNA nuclease of pUC19 plasmid DNA. The docking energies of the ligands ( ) and complexes () were observed in the range of -265.14 to -284.33 kJ mol. The synthesized Pt(ii) complexes () were screened against the MCF-7 (human breast adenocarcinoma) and HCT-116 (human colon carcinoma) cancer cell lines.

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New binary and ternary platinum(II) formamidine complexes: Synthesis, characterization, structural studies and in-vitro antitumor activity

Cited by 17 publications

References 32 publications

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

New dinuclear palladium(ii) complexes with formamidine and bridged pyrophosphate ligands

Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes

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