New biocompatible hydroxy double salts and their drug delivery properties

Abstract

Two novel biocompatible hydroxy double salts (HDSs) have been synthesised, loaded with the drug naproxen, and formulated into tablets.

Biocompatible hydroxy double salts as delivery matrices for non-steroidal anti-inflammatory and anti-epileptic drugs

“…The X-ray diffraction (XRD) data in Figure 2 showed that the preparation of the biocompatible HDS was successful, and in accordance with the previous report (Kaassis et al, 2016a) c It should be noted that these systems are biphasic. The formula depicted is an overall empirical formula for the solid material isolated.…”

“…Synthesis was performed following the methods reported in our previous study (Kaassis et al, 2016a). Following a range of optimisation studies, we prepared HDSs with M:Zn ratios as close to 1:1 as we could obtain.…”

“…In order to ameliorate this issue, we recently synthesised new HDSs based on Mg/Zn and Fe/Zn (Kaassis et al, 2016a). We further demonstrated that they could be used as delayed and extended release mechanisms for the non-steroidal anti-inflammatory drug (NSAID) naproxen.…”

Layered gadolinium hydroxides for simultaneous drug delivery and imaging

“…There are four synthesis routes that have been commonly employed: ion exchange (replacement of an initial interlayer anion such as Cl -or NO 3 -with the drug), [19][20][21] reconstruction (calcination followed by reacting the calcined LDH with a solution of the drug), 22,23 exfoliation-reassembly (separation of the LDH into single layers, and then reassembly in a solution of the drug), 24 and coprecipitation (addition of a mixture of metal salts to an alkaline solution of the drug of interest to prepare an intercalate in a single-step). [25][26][27][28] Beyond LDHs, there exist other layered hydroxides which can anion-exchange and have been explored for drug delivery, such as the hydroxy double salts 29,30 or layered rare earth hydroxides (LRHs). LRHs with general formula [Ln(OH) 2 ]A n-1/n ·yH 2 O have been known for decades, but only infrequently studied since the 1970s.…”

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

“…A plethora of nanocarriers with organic and inorganic origins has been employed over the years to encapsulate or to adsorb drugs (Madni et al, ). Among the inorganic nanocarriers, significant amount of work has been performed using iron oxide nanoparticles (IONPs) (Arias et al, ; Chandra Mohanta, Saha, & Sujatha Devi, ; El‐Boubbou, ; J. F. Liu et al, ; Marcu et al, ; Vallabani & Singh, ; Vangijzegem, Stanicki, & Laurent, ), mesoporous silica nanoparticles (Bharti, Gulati, Nagaich, & Pal, ; Dayana, Isa, Ahmad, Basyaruddin, & Rahman, ; Vallet‐Regí, Colilla, Izquierdo‐Barba, & Manzano, ; P. Zhao et al, ; Y. Zhou, Quan, Wu, Zhang, & Niu, ), and double layered hydroxides(Bi, Zhang, & Dou, ; Kaassis, Wei, & Williams, ; Ladewig, Xu, & Lu, ; Rives, del Arco, & Martín, ; H. Wang, Wu, Zheng, & Cheng, ; Y. Xu et al, ; K. Zhang et al, ). Liposomes (Alavi, Karimi, & Safaei, ; Antimisiaris, ; Dimov, Kastner, Hussain, Perrie, & Szita, ; Sercombe et al, ; Zylberberg & Matosevic, ), carbon nanotubes (Bianco, Kostarelos, & Prato, ; Corma, Díaz, Arrica, Fernández, & Ortega, ; Elhissi, Ahmed, Dhanak, & Subramani, ; Z. Liu et al, ; Z. Liu, Sun, Nakayama‐Ratchford, & Dai, ; Z. Liu, Tabakman, Welsher, & Dai, ; Meng, Zhang, Lu, Fei, & Dyson, ; Ojima et al, ; W. Zhang, Zhang, & Zhang, ), dendrimers (Chauhan, ; Huang & Wu, ; Markowicz‐Piasecka & Mikiciuk‐Olasik, ; Mendes, Pan, & Torchilin, ; Pandita, Poonia, Kumar, Lather, & Madaan, ; Parajapati et al, ), micelles, solid lipid nanoparticles, polymeric nanoparticles, and nanogels are highlighted as organic carriers (Madni et al, ).…”