New Biological Effect of the Gases of the Helium Group

Schreiner, H. R.; Gregoire, R. C.; Lawrie, James A.

doi:10.1126/science.136.3516.653

Cited by 27 publications

(13 citation statements)

References 12 publications

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“…The relationship between the physical properties of such gases and effects of their biological activity are recognised [7,20,21,22]. Based on the results of this study it appears that within the applied pressure range /up to 4 atm/, the narcotic effects and toxicity of the mixtures used were not revealed.…”

Section: Discussionmentioning

confidence: 72%

“…The result obtained in the experiment of breathing with argon mixture is associated with disorders in the respiratory mechanics resulting from the high density of this mixture. In our study, the Ar/02 mixture at 4 atm was 6.61 times denser than air, and it appears that in a long-term physical activity it would lead to respiratory failure [5,7,21,22].…”

Section: Discussionmentioning

confidence: 93%

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The Effect of Breathing Mixtures on Physical Capacity of Rats in Hyperbaric Conditions

Doboszyński¹,

Łokucijewski²,

Siermontowski³

et al. 2017

Polish Hyperbaric Research

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The purpose of the study was to determine the effect of composition of various breathing mixes on physical capacity of rats swimming in hyperbaric conditions. The said effect was determined on the basis of results of a swim test performed in a pressure chamber. The study was performed with the use of atmospheric air, a mixture of nitrogen and oxygen (N2/02) at a ratio of 89.5/10 and 92/7.5, as well as a mixture of argon and oxygen at a ratio of 79.5/20 (Ar/02). The tests were conducted at a pressure range between 0-4 atm. The results suggest that the physical capacity of the tested animals decreased along with pressure increase regardless of the breathing mix used. Due to the fact that the burdening of rats with physical effort in hyperbaric conditions intensifies the adverse effects of components of breathing mixes on their performance, it seems appropriate to continue the study of physiological responses to breathing mixtures of various compositions in human body subjected to physical effort while under water.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 93%

The Effect of Breathing Mixtures on Physical Capacity of Rats in Hyperbaric Conditions

Doboszyński¹,

Łokucijewski²,

Siermontowski³

et al. 2017

Polish Hyperbaric Research

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“…Increasing the ambient temperature (T a ) at 1 atm, and thus decreasing the driving force for heat loss, decreases the difference between V O 2 of rats in air and that in He [26]. Although there seems to be an effect on the metabolic rate, depending on the gas mixture used, that can be attributed to the thermal properties of the gas mixture, many reports of metabolic disturbances in tissue slices [29], insects [8], microorganisms [36], whole-animal studies in mammals [7,21,23], and inhibition of enzyme activity in vitro [35] have suggested other possible mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Calorimetry and respirometry in guinea pigs in hydrox and heliox at 10–60 atm

Fahlman

Kaveeshwar

Tikuisis³

et al. 2000

Pflugers Arch - Eur J Physiol

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We used direct calorimetry and respirometry to measure the total rate of heat loss (Qsigma) and of oxygen consumption (VO2) in guinea pigs in 1-atm (0.1 MPa) air and at 10-60 atm in either heliox (98% He, 2% O2) or hydrox (98% H2, 2% O2). Our objective was to determine if the physiological responses to these two gas mixtures were different and, if so, whether the differences were attributable to the thermal characteristics of the gases alone or were confounded by additional mechanisms. At 10-40 atm, Qsigma and VO2 were not significantly different in the two gas mixtures, whereas at 60 atm, Qsigma and VO2 were significantly higher in heliox than in hydrox. The VO2/Qsigma ratio suggested that the animals were not in thermal equilibrium in hyperbaria. Based solely on the differing thermal properties of the gas mixtures, a mathematical model predicted a Qsigma that was higher in hydrox than in heliox at all pressures. Two plausible explanations are suggested: one is an adaptive lowering of the surface temperature as a physiological response of the animal to the thermally more stressful hydrox environment, and the other is related to the narcotic suppression of the animal's activity by hydrox.

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“…Substitution of helium or argon for the nitrogen in air at one atmosphere apparently has no effect on the growth and gas exchange of Chlorella pyrenoidosa (1). Experiments with Neuspora crassa grown in atmospheres of helium, neon, nitrogen, argon, krypton, and xenon showed an inverse relationship between growth rate of the organism and the square root of the molecular weight of the gas (6). Latterell (3) reported a significant decrease in germination when rye seeds were exposed to a helium atmosphere at 760 mm of Hg.…”

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confidence: 99%