New biomorphic SiC ceramics coated with bioactive glass for biomedical applications

González, P.; Serra, J.; Liste, S.; Chiussi, S.; León, B.; Pérez‐Amor, M.; Martı́nez-Fernández, J.; Arellano‐López, A.R. de; Varela‐Feria, F. M.

doi:10.1016/s0142-9612(03)00405-8

Cited by 153 publications

(74 citation statements)

References 17 publications

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“…Este líquido emula las condiciones iónicas del plasma sanguíneo y constituye una primera prueba del comportamiento del material cuando se encuentra en un ambiente similar al de los fluidos corporales. Cuando un vidrio bioactivo se sumerge en este fluido su capa superficial sufre una serie de reacciones que finalizan con la formación de dos capas, una de SiO 2 sobre el vidrio original, y otra de naturaleza apatítica, compuesta por hidroxilapatita carbonatada, sobre la sílica (4,7,11,12). La aparición de esta última es una prueba de la bioactividad de un material, ya que para que se produzca el enlace del material a los tejidos es necesaria su presencia (7).…”

Section: Resultsunclassified

“…Dentro de este tipo de solución se ha propuesto una nueva clase de implante que consiste en el uso de sustratos de carburo de silicio biomórfico recubiertos de vidrio bioactivo mediante Depósito por Láser Pulsado (PLD) (4). Este nuevo dispositivo toma del sustrato su ligereza debido a una baja densidad, resistencia mecánica y elevada porosidad intrínseca proveniente de la madera de origen y perfeccionada por la evolución natural (4-6); y del recubrimiento de vidrio, la capacidad de originar una capa de naturaleza apatítica similar al hueso cuando entra en contacto con los fluidos corporales que permite la unión química a los tejidos vivos (7).…”

Section: Introductionunclassified

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Estudio de la Citotoxicidad de Cerámicas Biomórficas de SiC Recubiertas con Vidrio Bioactivo

Borrajo¹,

González²,

Serra³

et al. 2006

Bol. Soc. Esp. Ceram. Vidr.

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La necesidad de desarrollar nuevos implantes basados en materiales bioactivos que sean capaces de soportar grandes cargas mecánicas ha llevado a la producción de sustratos metálicos recubiertos con cerámicas bioactivas. Recientemente se ha propuesto un dispositivo alternativo que consiste en un sustrato de carburo de silicio (SiC) biomórfico recubierto con vidrio bioactivo, mediante la técnica de Depósito por Láser Pulsado (PLD), y que dispone de la resistencia mecánica adecuada, además de gran ligereza y una porosidad intrínseca muy favorable de cara a la implantación. En este trabajo se presenta un estudio interdisciplinar de este nuevo material centrado en la morfología y porosidad de sustratos de SiC provenientes de diferentes maderas, la bioactividad de los recubrimientos producidos por PLD y en la evaluación in vitro con células de osteosarcoma MG-63 con la que se ha determinado la citotoxicidad de estos materiales y se ha estudiado la influencia de los mismos en la adhesión y la proliferación celular. Palabras clave: Carburo de silicio biomórfico, Depósito por Láser Pulsado, bioactividad, test de proliferación celular, vidrio biaoctivo. Cytotoxicity study of biomorphic SiC ceramics coated with bioactive glass.In the past years there was a need to develop new tough bioactive materials capable to resist high loads when implanted in the body, that led to the production of bioactive coatings on metallic substrates. A new approach, which consists of biomorphic silicon carbide (SiC) coated with bioactive glass by Pulsed Laser Deposition (PLD), was recently presented. This new material joins the high mechanical strength, lightness and porosity of biomorphic SiC and the bioactive properties of PLD glass films. In this work, a multiple evaluation of this new material is presented starting from the biomorphic SiC morphology and porosity, following with the bioactivity in simulated body fluid of the coatings, and ending with a deep in vitro study with MG-63 cells. The citotoxicity of the SiC coated and uncoated and the cell proliferation and attachment were studied. Keywords: Biomorphic silicon carbide, Pulsed Laser Deposition, bioactivity, cell proliferation test, bioactive glass INTRODUCCIÓNDesde hace varias décadas se vienen utilizando materiales cerámicos para reparar o reconstruir partes del cuerpo dañadas, enfermas o desgastadas (1). Estos materiales se conocen con el nombre de biocerámicas y se clasifican, en función de su respuesta biológica, en inertes, bioactivas o reabsorbibles (1,2). Las cerámicas bioactivas han despertado un gran interés ya que dan lugar a un enlace interfacial muy fuerte entre el implante y el tejido vivo originando una mejor fijación del mismo en comparación con los materiales inertes. Sin embargo, el principal problema de las cerámicas bioactivas reside en su debilidad mecánica, que limita su uso a aplicaciones con bajas necesidades de carga. Ello ha llevado al desarrollo de dispositivos formados por un sustrato de resistencia adecuada recubierto con una cerámica bioactiva que posibi...

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Section: Resultsunclassified

Section: Introductionunclassified

Estudio de la Citotoxicidad de Cerámicas Biomórficas de SiC Recubiertas con Vidrio Bioactivo

Borrajo¹,

González²,

Serra³

et al. 2006

Bol. Soc. Esp. Ceram. Vidr.

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“…A porous carbon material which conserves the original wood microstructure is thus obtained, which is then machined to near network optimized for fluid transport as well as compressive and bending strength has made bioSiC an interesting material in medical implants and prosthetics, specially in load-bearing bone substitution. BioSiC is non-cytotoxic and posesses favorable osteo-integration properties when coated with a bioactive glass [7][8][9][10][11][12][13], nanostructured elecrophoretic hydroxiapatite [14] and in-vitro precipitated HAP [15]. A hybrid prosthetic device containing an outer shell of porous bioSiC and an inner shell of hydroxyapatite/collagen was recently demonstrated to be safe and feasible, and showed enhanced bone-to-implant contact as well as new bone growth [16].…”

Section: Introductionmentioning

confidence: 99%

Sliding wear resistance of biomorphic SiC ceramics

Vera

Ramírez‐Rico

Fernandez

et al. 2015

International Journal of Refractory Metals and Hard Materials

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Biomorphic SiC ceramics were fabricated from four different wood precursors and their Knoop hardness and sliding wear resistance when sliding against a Si3N4 ball in air were studied.Tribological experiments were performed using a pin on disk apparatus, under normal loads of 2 and 5 N, at a sliding speed of 100 mm/s. The effects of specimen porosity and microstructure on measured wear were evaluated. A commercial sintered silicon carbide ceramic was also tested for comparison. Small differences in friction coefficient comparable to monolithic SiC ceramics were obtained. Several concurrent wear mechanisms are taking place: microfracture, plastic deformation in the Si phase and oxidation of the Si and/or SiC phase. The presence of an oxide tribolayer was assessed using fluorescence microscopy. Wear rates were found to scale with SiC content and depend on residual porosity in the composite.

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“…ChongTian et al adopt new techniques to prepare silicon carbide (SiC) foams, which possess high strength, appropriate elastic modulus and good machinable properties 9,10) . SiC foam has attracted much more research interest in the field of biomaterial in the past decade [11][12][13] . Previous experimental results already suggest that this new material has good biological safety 14) .…”

Section: Introductionmentioning

confidence: 99%

The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts

Yuan

Hao

et al. 2015

J. Hard Tissue Biology.

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The objective of this study was to investigate the possibility of silicon carbide (SiC) foam as an alternative material for porous hydroxyapatite (HA). The characters of two materials were evaluated and compared by a series of in vitro biological tests. The result of the morphology showed that SiC foam provided beneficial structure for cell migration. On the level of primary-osteoblasts proliferation measured by MTT assay and cell cycle analysis showed that the proliferation rate increased in the early stage on HA but in the advanced stage on SiC foam. There was no significant difference between the two materials on the level of cell differentiation detected by alkaline phosphatase (ALP) assay and real-time PCR. All of the results indicated that SiC foam was comparable to HA in terms of biocompatibility and bone conductivity.

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New biomorphic SiC ceramics coated with bioactive glass for biomedical applications

Cited by 153 publications

References 17 publications

Estudio de la Citotoxicidad de Cerámicas Biomórficas de SiC Recubiertas con Vidrio Bioactivo

Estudio de la Citotoxicidad de Cerámicas Biomórficas de SiC Recubiertas con Vidrio Bioactivo

Sliding wear resistance of biomorphic SiC ceramics

The Effects of SiC Foams on Cell Proliferation and Differentiation in Primary Osteoblasts

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