New bone formation induced by surface strontium‐modified ceramic bone graft substitute

Park, Jin Woo; Dg, Kang; Hanawa, Takao

doi:10.1111/odi.12381

Cited by 10 publications

(7 citation statements)

References 30 publications

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“…In dentistry, bone loss may occur in tooth extractions, oncological rejections, fractures, and traumas 1 . Dental implant placement is one of the most frequent situations where bone volume augmentation is needed 2,3 . The current gold standard technique for bone regeneration is the use of autologous graft, which may create morbidity for the donor and has a limitation in the bone volume that can be donated 4 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

Grazioli

Silva

Souza

et al. 2020

J Biomedical Materials Res

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Novel poly(vinyl alcohol)/chondroitin sulfate (PVA/CS) composite hydrogels containing hydroxyapatite (HA) or Sr‐doped HA (HASr) particles were synthesized by a freeze/thaw method and characterized aiming towards biomedical applications. HA and HASr were synthesized by a wet‐precipitation method and added to the composite hydrogels in fractions up to 15 wt%. Physical–chemical characterizations of particles and hydrogels included scanning electron microscopy, energy‐dispersive spectroscopy, Fourier‐transform infrared spectroscopy, X‐ray diffraction, thermogravimetry, porosity, compressive strength/elastic modulus, swelling degree, and cell viability. Particles were irregular in shape and appeared to have narrow size variation. The thermal behavior of composite hydrogels was altered compared to the control (bare) hydrogel. All hydrogels exhibited high porosity. HA/HASr particles reduced total porosity without reducing pore size. The mechanical strength was improved as the fraction of HA or HASr was increased. HASr particles led to a faster water uptake but did not interfere with the total hydrogel swelling capacity. In cell viability essay, increased cell growth (above 120%) was observed in all groups including the control hydrogel, suggesting a bioactive effect. In conclusion, PVA/CS hydrogels containing HA or HASr particles were successfully synthesized and showed promising morphological, mechanical, and swelling properties, which are particularly required for scaffolding.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

Grazioli

Silva

Souza

et al. 2020

J Biomedical Materials Res

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“…Also Park et al, demonstrated that strontium modified ceramic bone graft substitute showed early osteoblast differentiation. ALP activity, OC, transcriptional factors like Runx2 and Osterix was found to be upregulated comparing with other samples without Sr (33). Moreover, presence of Sr ions can interact and down regulate release of proinflammatory cytokine like TNF-α (tumor necrosis factor α) and IL-1 (interleukin 1) (14).…”

Section: Expression Changes Of Bone Biomarkersmentioning

confidence: 93%

“…Many studies have been investigating Sr effects in different biomaterials and results are encouraging. Strontium ions are being incorporated in different biomaterials and metallic implants like synthetic hydroxyapatites, glass ceramics, bioactive glasses, calcium phosphate cements or metallic implants with different alloys, searching for increased bone quality and formation in bone tissue defects or around osseointegrating implants (22,25,29,33,52). In recent years there is a development of injectable materials for filling bone defects as minimally invasive techniques.…”

Section: Strontium and Biomaterialsmentioning

confidence: 99%

Does Local Application of Strontium Increase Osteogenesis and Biomaterial Osteointegration in Osteoporotic and Other Bone Tissue Conditions: Review of Literature

Zariņš¹,

Pilmane

Sidhoma

et al. 2016

Acta Chirurgica Latviensis

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SummaryOsteoporosis and other pathological bone conditions can impair bone regeneration properties, consuming in increased morbidity and decreased quality of life. Changes of bone healing can result in poor osteointegration and surgical failures if implants are used. To overcome and facilitate bone regeneration, more attempts are made to develop an ideal synthetic scaffold with better biocompatibility, osteoconductivity, bioactivity, osteoinductivity and interconnected porosity. It is considered that strontium, being similar to calcium, can be incorporated into the mineral phase of the bone remodeling. This quality had led strontium to be used as an osteoporotic medication to improve quality of bone and to reduce the risk of bone fractures. Also local application of strontium has been widely used within different biomaterials in tissue engineering researches.In this review authors wanted to provide an overview about strontium, its mechanisms of action in bone tissue and initiated changes of bone remodeling within biomaterials.

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“…The local use of strontium for promoting bone growth usually involves the incorporation of strontium into bone grafts [ 20 , 21 , 22 ]. Other strontium delivery methods include strontium associated with collagen sponge [ 23 ], strontium-containing collagen membrane and strontium dissolved in gel [ 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Polybutylcyanoacrylate Nanoparticles as a Protos Delivery Vehicle on Dental Bone Formation

Chang

Chung

Chiu

et al. 2021

IJMS

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Background: Dental implants are commonly used for missing teeth, for which success depends heavily on the quality of the alveolar bone. The creation of an ideal implant site is a key component in shortening the treatment time, which remains clinically challenging. Strontium ranelate (Protos) is an anti-osteoporotic agent which has previously been used to promote bone formation, however the systemic use of Protos has been linked to serious cardiovascular and venous thromboembolic events, thus local delivery strategies may be better suited for this purpose. In this study, a biodegradable, and biocompatible nanocarrier “polybutylcyanoacrylate” (PBCA) loaded with strontium was constructed and its ability to promote bone formation was assessed. Methodology: PBCA nanoparticles loaded with strontium (PBCA-Sr NPs) were synthesized using the emulsion polymerization method, and their physical properties (zeta potential, size and shape) and entrapment efficiency were characterized. Committed MSCs (osteoblasts) were derived from the differentiation of cultured rat mesenchymal stem cells (MSC), which were tested with the PBCA-Sr NPs for cytotoxicity, inflammatory response, bone formation and mineralization. Scanning electron microscopy was performed following a 7-day treatment of PBCA-Sr NPs on decellularized procaine mandibular bone blocks grafted with osteoblasts. Results: Spherical PBCA-Sr NPs of 166.7 ± 2.3 nm, zeta potential of −1.15 ± 0.28 mV with a strontium loading efficiency of 90.04 ± 3.27% were constructed. The presence of strontium was confirmed by energy-dispersive X-ray spectroscopy. Rat committed MSCs incubated in PBCA-Sr NPs for 24 hrs showed viabilities in excess of 90% for concentrations of up to 250 ug/mL, the cellular expression of osteocalcin and alkaline phosphatase were 1.4 and 1.3 times higher than the untreated control, and significantly higher than those treated with strontium alone. Bone formation was evident following osteoblast engraftment on the decellularized procaine mandibular bone block with PBCA-Sr NPs, which appeared superior to those treated with strontium alone. Conclusion: Treatment of committed MSCs with PBCA-Sr NPs showed higher expression of markers of bone formation when compared with strontium alone and which corresponded to greater degree of bone formation observed on the 3-dimensinal decellularized procaine mandibular bone block. Further quantitative analysis on the extent of new bone formation is warranted.

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New bone formation induced by surface strontium‐modified ceramic bone graft substitute

Abstract: These results suggest that the surface Sr modification by wet chemical treatment is a promising approach to enhance the early bone healing capacity of osteoconductive ceramic bone substitutes.

Cited by 10 publications

References 30 publications

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

Does Local Application of Strontium Increase Osteogenesis and Biomaterial Osteointegration in Osteoporotic and Other Bone Tissue Conditions: Review of Literature

The Effect of Polybutylcyanoacrylate Nanoparticles as a Protos Delivery Vehicle on Dental Bone Formation

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