New Chiral Phosphorus Ligands for Enantioselective Hydrogenation

Efficient asymmetric hydrogenation with rhodium complexes of C1-symmetric 2,5-dimethylphospholane-diphenylphosphines

“…To a solution of 1a (220 mg, 0.58 mmol) in CH 2 were determined by comparison with reference compounds and literature values. 22 Retention times for the products from substrate D were 11.08 and 11.27 min, from substrate E were 37.50 and 38.10 min, from substrate F were 5.1 and 5.5 min, from substrate G were 6.3 and 6.6 min and from substrate H were 22 and 27 min.…”

“…1 Over the last 30 years, hundreds of chiral diphosphine ligands have been screened 2 for asymmetric hydrogenation and from this empirical endeavour, some guiding principles for the design of diphosphines for efficient asymmetric hydrogenation have emerged. These include, the presence of a rigid backbone, PPh 2 groups or 2,5-dimethylphospholanes; two of the most successful chiral diphosphines, binap 3 and Duphos 4 embody these features.…”

New Diphosphane Ligands Based on Bisphenol A Backbones − Synthesis and Coordination Chemistry

“…[1,2] Numerous families of novel ligands have been synthesized, [3] with emphasis on cis-chelation to form monomeric metal complexes. As well as designing ligands based on desired behaviour towards transition metals and the catalytic activity of the resultant systems, the approach of modular design and availability from cheap resources has gained significant importance.…”

Study on the Highly Selective Asymmetric Hydrogenation of Polyfunctionalized Carbonyl Substrates

“…Noyori 等 [2] 发展的 BINAP 配体, 使得羰 基化合物的不对称氢化在有机合成中的应用越来越广 泛; 在此基础上发展出来的 SegPhos 系列配体, 是一个 比 BINAP 更有效的配体. 迄今为止, 许多以联芳基为 骨架的配体被设计合成出来 [3] (Scheme 1), 在官能团化 的羰基化合物的氢化中取得了优异的结果.…”