2012
DOI: 10.1016/j.gie.2011.10.037
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New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video)

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Cited by 69 publications
(52 citation statements)
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“…It has been suggested that for defects smaller than the width of the open clip it should be clipped in a 'side to center' manner; when the defect is slightly larger than the width of the open clip, the diameter can be reduced by air suction. In case of large defects, the first clip is the most critical and a recent proposal for certain cases is to perform small incisions around to provide a better grip for the clip [95]. Combined methods are also a good approach for larger defects, for instances, hemoclips plus Endoloop [96,97], plus omental patch [93] or plus band ligation [98].…”
Section: Endoscopic Closure Methodsmentioning
confidence: 99%
“…It has been suggested that for defects smaller than the width of the open clip it should be clipped in a 'side to center' manner; when the defect is slightly larger than the width of the open clip, the diameter can be reduced by air suction. In case of large defects, the first clip is the most critical and a recent proposal for certain cases is to perform small incisions around to provide a better grip for the clip [95]. Combined methods are also a good approach for larger defects, for instances, hemoclips plus Endoloop [96,97], plus omental patch [93] or plus band ligation [98].…”
Section: Endoscopic Closure Methodsmentioning
confidence: 99%
“…1 It should be emphasized, as indicated in the article, that we believe the closure technique suitable for mucosal defects from en bloc ESDs with an extremely low incidence of residual tumors rather than piecemeal EMRs. Although the effectiveness of the closure technique for large mucosal defects after ESDs has not yet been evaluated "in prospective studies involving larger numbers of patients," as we have recommended, negative data on the effectiveness of clipping after colonoscopic polypectomy previously reported by Shioji et al 2 should not be applied to such defects because of substantial differences in the sizes of mucosal defects between polypectomies and ESDs.…”
Section: Responsementioning
confidence: 95%
“…However, it adds considerable expense to the procedure and technical challenges including defect size may limit universal application of this technique currently [64]. Novel methods to facilitate clip closure of large defects, such as creating small defects to allow clip purchase on normal mucosa after colonic ESD, warrant further evaluation in randomized trials [65]. Further randomized studies to define the role of clip closure and explore application of novel 'spray on' adherent mechanical barriers [66], particularly in large resection defects, are required.…”
Section: Bleedingmentioning
confidence: 99%