New comonomers in malic acid polyesters

Telegdi, J.; Trif, László; Nagy, Edit; Mihály, Judith; Molnár, Nikoletta

doi:10.1007/s10973-017-6230-7

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…Small molecules sourced from biomass 108 include diacids and diols for stoichiometric polycondensations, 102,109,110 hydroxyacids for polycondensations, [111][112][113][114][115] cyclic monomers for ring opening polymerisations, [116][117][118][119][120][121][122] and agents for branching and crosslinking. 111,123 A notable example utilised across different applications is poly(lactic acid) (PLA), which uses glucose-derived lactic acid as a feedstock.…”

Section: Bio-based Synthetic Polymersmentioning

confidence: 99%

Sustainable formulation polymers for home, beauty and personal care: challenges and opportunities

Picken,

Buensoz,

Price

et al. 2023

Chem. Sci.

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Section: Bio-based Synthetic Polymersmentioning

confidence: 99%

Sustainable formulation polymers for home, beauty and personal care: challenges and opportunities

Picken,

Buensoz,

Price

et al. 2023

Chem. Sci.

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“…This low M w product renders this method of production impracticable for biomedical purposes. To overcome these problems, hydroxyl-rich comonomers (e.g., β-cyclodextrin) have been recently employed to construct malic acid–based polyesters via direct condensation with techniques to remove water in a timely fashion [ 17 , 18 ].…”

Section: Chemical Synthesis Of Pmlamentioning

confidence: 99%

Polymalic acid for translational nanomedicine

Huang

Qian

et al. 2022

J Nanobiotechnol

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With rich carboxyl groups in the side chain, biodegradable polymalic acid (PMLA) is an ideal delivery platform for multifunctional purposes, including imaging diagnosis and targeting therapy. This polymeric material can be obtained via chemical synthesis, or biological production where L-malic acids are polymerized in the presence of PMLA synthetase inside a variety of microorganisms. Fermentative methods have been employed to produce PMLAs from biological sources, and analytical assessments have been established to characterize this natural biopolymer. Further functionalized, PMLA serves as a versatile carrier of pharmaceutically active molecules at nano scale. In this review, we first delineate biosynthesis of PMLA in different microorganisms and compare with its chemical synthesis. We then introduce the biodegradation mechanism PMLA, its upscaled bioproduction together with characterization. After discussing advantages and disadvantages of PMLA as a suitable delivery carrier, and strategies used to functionalize PMLA for disease diagnosis and therapy, we finally summarize the current challenges in the biomedical applications of PMLA and envisage the future role of PMLA in clinical nanomedicine. Graphical Abstract

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Polymeric Nano-Composite Scaffolds for Bone Tissue Engineering: Review

Kumar

Ahuja²

2022

Biodegradable and Environmental Applications of Bionanocomposites

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New comonomers in malic acid polyesters

Cited by 7 publications

References 32 publications

Sustainable formulation polymers for home, beauty and personal care: challenges and opportunities

Sustainable formulation polymers for home, beauty and personal care: challenges and opportunities

Polymalic acid for translational nanomedicine

Polymeric Nano-Composite Scaffolds for Bone Tissue Engineering: Review

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