New compound from the plant origin of propolis from Lombok, Indonesia and its antibacterial activity

Mizuno, Sayaka; Miyata, Ryo; Mukaide, Kazuma; Honda, Sari; Sukito, Agus; Sahlan, Muhamad; Taniguchi, Tohru; Kumazawa, Shigenori

doi:10.1016/j.rechem.2021.100276

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…Besides, the presence of anti‐ bacillus activities among the chromanone acids could be due to their stereochemical differences at two methyl chiral centers (C‐2 and C‐3) in calolongic acid (2) , caloteysmannic acid (3) , and isocalolongic acid (4) which might influence the overall anti‐ bacillus activities against all tested strains [26] . It can be observed that the cis ‐configured dimethyl groups at C‐2 and C‐3 in caloteysmannic acid (3) and isocalolongic acid (4) is an important factor in showing its anti‐ bacillus effects [27,28] .…”

Section: Resultsmentioning

confidence: 99%

“…To our knowledge, this is the first report on these phytoconstituents isolated from the stem bark of C. havilandii, though these compounds were reported to be isolated previously from other Calophyllum species. [2,27,28]…”

Section: Characterization Of the New 4-propyldihydrocoumarin Derivati...mentioning

confidence: 99%

“…acid (2), caloteysmannic acid (3), and isocalolongic acid (4) which might influence the overall anti-bacillus activities against all tested strains. [26] It can be observed that the cis-configured dimethyl groups at C-2 and C-3 in caloteysmannic acid (3) and isocalolongic acid (4) is an important factor in showing its antibacillus effects. [27,28] Meanwhile, its trans-configured isomer, calolongic acid (2) showed low to no inhibition towards all tested strains.…”

Section: Anti-bacillus Activitymentioning

confidence: 99%

“…[26] It can be observed that the cis-configured dimethyl groups at C-2 and C-3 in caloteysmannic acid (3) and isocalolongic acid (4) is an important factor in showing its antibacillus effects. [27,28] Meanwhile, its trans-configured isomer, calolongic acid (2) showed low to no inhibition towards all tested strains. However, additional chiral center at acidic (phenyl) side chain in caloteysmannic acid (3) could also attributed to its anti-bacillus properties.…”

Section: Anti-bacillus Activitymentioning

confidence: 99%

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Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities

Zailan,

Karunakaran,

Santhanam

et al. 2024

Chemistry & Biodiversity

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The genus Calophyllum from the family Calophyllaceae has been extensively investigated in the past due to its rich source of bioactive phenolics such as coumarins, chromanones, and xanthones. In this study, phytochemical investigation on the stem bark of Calophyllum havilandii has afforded a new 4‐propyldihydrocoumarin derivative, havilarin (1) together with calolongic acid (2), caloteysmannic acid (3), isocalolongic acid (4), euxanthone (5), and β‐sitosterol (6). The chemical structure of compound 1 was elucidated and established based on detailed spectroscopic techniques, including MS, IR, UV, 1D and 2D NMR. The results of anti‐bacillus study indicated that the chloroform extract showed promising activities with MIC value ranging between 0.5 to 1 μg/mL on selected bacillus strains. Besides, the plant extracts and compounds 1‐4 were assessed for their cytotoxicity potential on HL‐7702 cell line. All the tested plant extracts and respective chemical constituents displayed non‐cytotoxic activity on HL‐7702 cell line.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Of the New 4-propyldihydrocoumarin Derivati...mentioning

confidence: 99%

Section: Anti-bacillus Activitymentioning

confidence: 99%

Section: Anti-bacillus Activitymentioning

confidence: 99%

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Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities

Zailan,

Karunakaran,

Santhanam

et al. 2024

Chemistry & Biodiversity

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“…Countries in Asia with tropical climates, namely Indonesia and Malaysia, also exhibit different botanical sources. Propolis found in East Java, Indonesia was shown to be botanically sourced from Mangifera indica L. and Macaranga tanarius L., and Calophyllum inophyllum Linn was confirmed to be the botanical source for propolis found in Lombok, Indonesia (Mizuno et al, 2022; Trusheva et al, 2011). In the northern and southern regions of Peninsular Malaysia, the predominant botanical source was Acacia mangium and other shrubs and fruit orchards may also contribute as sources (Tuan Ismail et al, 2018).…”

Section: Properties Of Propolismentioning

confidence: 99%

Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn

Manginstar,

Tallei,

Niode

et al. 2023

Phytotherapy Research

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Burns can cause inflammation and delayed healing, necessitating alternative therapies due to the limitations of conventional treatments. Propolis, a natural bee‐produced substance, has shown promise in facilitating burn healing. This literature review provides a comprehensive overview of propolis' mechanisms of action, wound‐healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti‐inflammatory properties, making it a promising candidate for managing skin burn injuries. It helps prevent infections, neutralize harmful free radicals, and promote a well‐balanced inflammatory response. Moreover, propolis aids in wound closure, tissue regeneration, collagen synthesis, cellular proliferation, and angiogenesis, contributing to tissue regeneration and remodeling. The article discusses various propolis extracts, extraction methods, chemical composition, and optimized formulations like ointments and creams for burn wound treatment. Considerations regarding dosage and safety are addressed. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages. Nevertheless, propolis' natural origin and demonstrated benefits make it a compelling avenue for burn care exploration, potentially complementing existing therapies and improving burn management outcomes.

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Global Trends on the Research of Plant Resin Use by Stingless Bees (1985–2022) and Apis mellifera (1967–2022): A Bibliometric Analysis

Vit,

Wang,

Massaro

et al. 2024

Stingless Bee Nest Cerumen and Propolis, Volume 1

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New compound from the plant origin of propolis from Lombok, Indonesia and its antibacterial activity

Cited by 12 publications

References 20 publications

Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities

Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities

Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn

Global Trends on the Research of Plant Resin Use by Stingless Bees (1985–2022) and Apis mellifera (1967–2022): A Bibliometric Analysis

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