New Compounds: Anils

Luts, Heino A.

doi:10.1002/jps.2600601237

Journal of Pharmaceutical Sciences

1971

DOI: 10.1002/jps.2600601237

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New Compounds: Anils

Heino A. Luts¹

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1972

1979

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“…Substituted benzylidenes have been reported to possess central nervous system (CNS) activi ties (12). Attempts have been made to correlate the anticonvulsant activity of substituted benzylidenes with their MAO inhibitory effec tiveness (6).…”

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confidence: 99%

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

Jaiswal¹,

Gupta²,

Kumar³

et al. 1979

Pharmacology

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The present study reports the synthesis and characterization of eight new substituted benzylideneamino guanidines. All compounds inhibited the monoamine oxidase (MAO) activity of rat brain mitochondria in vitro. The I₅₀ values were determined and were found to be in the range of 10^–4 to 10^–5 mol/l. Preincubation, dialysis and kinetic studies carried out with isolated brain mitochondria by conventional Dixon plot revealed reversible and noncompetitive type of MAO inhibition. These compounds were also screened for anticonvulsant and antidepressant activities. In the present series of compounds only one compound – 1-amino-3-(4-chloromethylbenzylidene-amino)guanidine hydroiodide – was found to afford 20% protection against pentetrazol-induced seizures in mice. 1-Amino-3-(3,4-dichlorobenzylideneamino)guanidine hydroiodide which produced maximum inhibition of MAO activity, also produced reversal of reserpine-induced sedation and miosis into excitation and mydriasis in mice.

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mentioning

confidence: 99%

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

Jaiswal¹,

Gupta²,

Kumar³

et al. 1979

Pharmacology

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ChemInform Abstract: NEUE ANILE

Luts¹

1972

Chemischer Informationsdienst

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New Compounds: Physiologically Active Amines and Amine Salts

Luts

Grattan²

1972

Journal of Pharmaceutical Sciences

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New Compounds: Anils

Cited by 5 publications

References 1 publication

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

ChemInform Abstract: NEUE ANILE

New Compounds: Physiologically Active Amines and Amine Salts

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