New concepts for the pathogenesis and management of aspirin-exacerbated respiratory disease

Sehanobish, Esha; Asad, Mohammad; Jerschow, Elina

doi:10.1097/aci.0000000000000795

Cited by 5 publications

(4 citation statements)

References 75 publications

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“…Individuals with AERD tend to have the most severe form of the disease and resist treatment [3]. AERD is characterized by high levels of type 2 innate immune cells, such as mast cells, eosinophils and basophils, with significant increases in the levels of traditional type 2 inflammatory mediators, such as interleukins (ILs) 4, 5 and 13 and eotaxins 1 and 2 [34][35][36][37]. According to our study, a significantly higher number of relapses after surgery occurred among AERD patients compared with the controls.…”

Section: Discussionmentioning

confidence: 99%

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Brescia,

Fabbris,

Calvanese

et al. 2023

Diagnostics

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Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and its course, as well as their potential use for a patient-tailored approach. By releasing IL-4, basophils play a crucial role in activating the Th2-mediated response. The main aim of this study was to, first, investigate the level of the pre-operative blood basophils’ values, blood basophil/lymphocyte ratio (bBLR) and blood eosinophil-to-basophil ratio (bEBR) as predictors of recurrent polyps after endoscopic sinus surgery (ESS) in AERD patients. The secondary aim was to compare the blood basophil-related variables of the AERD series (study group) with those of a control group of 95 consecutive cases of histologically non-eosinophilic CRSwNP. The AERD group showed a higher recurrence rate than the control group (p < 0.0001). The pre-operative blood basophil count and pre-operative bEBR were higher in AERD patients than in the control group (p = 0.0364 and p = 0.0006, respectively). The results of this study support the hypothesis that polyps removal may contribute to reducing the inflammation and activation of basophils.

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Section: Discussionmentioning

confidence: 99%

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Brescia,

Fabbris,

Calvanese

et al. 2023

Diagnostics

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“…В то же время бактериальная флора нарушает движение мерцательного эпителия, ухудшая дренажные функции и уменьшая бактерицидные свой ства секрета, снижает местную иммунологическую реакцию. Повышение эластичности и вязкости секрета, как правило, сопровождается снижением основных факторов, поддерживаю щих локальный иммунитет, например лизоцима, интерферонов, лактоферрина, IgA [33][34][35][36]. Переход слизистого секрета в слизисто-гнойный и гнойный сопровождается уменьшением продукции кислых и одновременным увеличением количества нейтральных муцинов [37,38].…”

Section: инфекции в оториноларингологииunclassified

“…2) Мукоактивные препараты, влияющие на свой ства секрета, количество и вязкость. Различают мукокинетики, влияющие на золь-слой секрета и улучшаю щие его подвижность; муколитики -воздействующие на реологические свой ства гель-слоя и уменьшаю щие вязкость и эластичность секрета; мукорегуляторы -регулирующие продукцию секрета дыхательных путей [33,44,45].…”

Section: лечение ларинготрахеитаunclassified

Acute respiratory infections of the upper respiratory tract, aspects of mucoactive therapy

Korkmazov,

Kornova,

Lengina

et al. 2024

Medicinskij sovet

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Introduction. Acute laryngotracheitis occurs at any age and is a complication of acute respiratory infection with a frequency of up to 40%. One of the main clinical symptoms is an unproductive paroxysmal cough. According to the literature, phytotherapy is a safe and effective part of conservative therapy and is included in clinical recommendations.Aim. To evaluate the effectiveness of the use of mucolytic phytopreparations in the treatment of acute respiratory infection complicated by laryngotracheitis.Materials and methods. A randomized simple controlled clinical trial was conducted in which 74 patients aged 18 to 45 years with acute laryngitis complicated by laryngotracheitis participated. All patients were randomly divided into 3 groups: group 1 (n = 24) received standard conservative therapy without mucolytic expectorants; group 2 (n = 25) – standard conservative therapy and acetylcysteine; group 3 (n = 25) – standard therapy using a herbal preparation based on ivy leaf extract in the form of syrup. Assessment of the severity of the main clinical symptoms and quality of life was carried out on the 5th, 7th and 10th day of therapy.Conclusions. The use of ivy leaf extract, which has a mucolytic and expectorant effect in complex therapy in patients with acute laryngotracheitis against the background of acute respiratory viral infection, allowed us to obtain stable positive dynamics in a shorter time (5th day of treatment) with the disappearance of all the main clinical symptoms on the 7th day.

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“…Так как основной жалобой пациента с АР при посещении врача является назальная обструкция, врач-оториноларинголог в процессе тщательного осмотра выявляет причину затрудненного носового дыхания. Важно объяснить пациенту на приеме, что причиной жалоб, с которыми он обратился, могут быть другие патологические состояния ВДП, например риносинусит с полипозом и без полипоза, деформация носовой перегородки (ДНП) в виде различных искривлений, образованием шипов и гребней, concha bullosa, гипертрофия аденоидов, аденоидиты, инородные тела, опухоли и т. д. После выявления сопутствующих патологических состояний, отягощаю щих течение АР, оториноларинголог должен предложить хирургическую коррекцию, но при этом обязательно разъяснить пациенту, что оперативное вмешательство не излечивает от АР, а облегчает носовое дыхание и ликвидирует воспалительный процесс и т. д. По литературным данным, аллергическая патология получила различные названия: «синобронхит», «синусопневмония», «синусобронхопневмональный синдром», «аденосинусобронхопневмония» [45][46][47]. При показаниях проводится соответствующая хирургическая коррекция с применением высокотехнологических методик, лазерных технологий [48][49][50][51].…”

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Quality of life of children with allergic rinitis and ways of correction

Korkmazov,

Lengina,

Dubinets

et al. 2023

Medicinskij sovet

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Introduction. Allergic rhinitis is a common disorder that significantly impairs the children’s quality of life. The problem is particularly pertinent in relation to the paediatric population living in areas with advanced manufacturing industries, where well-known trigger factors, being added by increased concentration of pollutants in the atmospheric air, further complicate the selection of an effective course of treatment.Aim. To determine the effectiveness of a course of treatment with an antihistamine medicine Cetirizine based on the assessment of quality-of-life criteria for children with intermittent allergic rhinitis (IAR) in the Chelyabinsk region.Materials and methods. A prospective study of 147 children with respiratory allergic diseases living in the Chelyabinsk region was conducted. The quality of life of children who received a course of treatment with the antihistamine medicine was assessed using the Paediatric Quality-of-Life inventory (PedsQL) that consisted of combined Likert scales (school life, social, physical functioning, etc.), clinical symptoms were assessed using a developed visual analogue scale.Results and discussion. The assessment findings confirmed that the use of Cetirizine in the complex therapy of intermittent allergic rhinitis and associated comorbid conditions made it possible to significantly improve the clinical symptoms and quality of life of children over the entire treatment period.The most striking positive response in the form of decreased nasal obstruction was seen during the prescribed treatment in patients of Groups 1 and 2. Thus, the filling VAS ratings for children with mild to moderate IAR showed that only 10 (20%) patients in Group 1 experienced mild nasal breathing difficulty. Patients with severe IAR reported a decrease in nasal obstruction only by the end of two-month treatment.Conclusion. Cetirizine demonstrated a good effect of blocking H1-histamine receptors, high bioavailability, good tolerability and safety in the treatment of allergic rhinitis in children with comorbid conditions.

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New concepts for the pathogenesis and management of aspirin-exacerbated respiratory disease

Cited by 5 publications

References 75 publications

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Acute respiratory infections of the upper respiratory tract, aspects of mucoactive therapy

Quality of life of children with allergic rinitis and ways of correction

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