New considerations regarding the risk assessment on Tartrazine

Elhkim, M. Ould; Héraud, Fanny; Bemrah, Nawel; Gauchard, Françoise; Lorino, Tristan; Lambré, Claude; Fremy, Jean Marc; Poul, J

doi:10.1016/j.yrtph.2006.11.004

Cited by 83 publications

(24 citation statements)

References 50 publications

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“…In this study, the highest exposure was found in a ‘health’ juice-based drink (Fallico et al 2011). In addition, a study in France estimated the exposure to Tartrazine as part of a risk assessment for this colour additive (Elhkim et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Exposure estimate for FD&C colour additives for the US population

Doell

Folmer

Lee

et al. 2016

Food Additives & Contaminants: Part A

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Dietary exposures to the seven food, drug, and cosmetic (FD&C) colour additives that are approved for general use in food in the United States were estimated for the US population (aged 2 years and older), children (aged 2–5 years) and teenage boys (aged 13–18 years) based on analytical levels of the FD&C colour additives in foods. Approximately 600 foods were chosen for analysis, based on a survey of product labels, for the levels of FD&C colour additives. Dietary exposure was estimated using both 2-day food consumption data from the combined 2007–10 National Health and Nutrition Examination Survey (NHANES) and 10–14-day food consumption data from the 2007–10 NPD Group, Inc. National Eating Trends – Nutrient Intake Database (NPD NET-NID). Dietary exposure was estimated at the mean and 90th percentile using three different exposure scenarios: low exposure, average exposure and high exposure, to account for the range in the amount of each FD&C colour additive for a given food. For all populations and all exposure scenarios, the highest cumulative eaters-only exposures in food were determined for FD&C Red No. 40, FD&C Yellow No. 5 and FD&C Yellow No. 6. In addition, the eaters-only exposure was estimated for individual food categories in order to determine which food categories contributed the most to the exposure for each FD&C colour additive. Breakfast Cereal, Juice Drinks, Soft Drinks, and Frozen Dairy Desserts/Sherbet (also referred to as Ice Cream, Frozen Yogurt, Sherbet (including Bars, Sticks, Sandwiches)) were the major contributing food categories to exposure for multiple FD&C colour additives for all three populations.

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Section: Introductionmentioning

confidence: 99%

Exposure estimate for FD&C colour additives for the US population

Doell

Folmer

Lee

et al. 2016

Food Additives & Contaminants: Part A

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“…Despite intolerance reactions in man such as urticaria (Rajan et al, 2014), estimated to be around 0.12% of the population (Elhkim et al, 2007), data regarding the metabolism of tartrazine in experimental animals and man is limited.…”

Section: Resultsmentioning

confidence: 99%

Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

et al. 2017

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HighlightsSystemic exposure to tartrazine results in hepatic periportal recruitment of inflammatory cells, increased serum alkaline phosphatase activity and mild hepatic periportal fibrosis.Tartrazine, its sulphonated metabolites and a common contaminant of the food additive do not interact with murine oestrogen receptors.Systemic exposure does not have an oestrogenic effect in mouse in vivo.Tartrazine, its sulphonated metabolites and a common contaminant of the food additive inhibited sulphotransferase, which may account for its hepatic effects after systemic exposure.The hepatic effects of tartrazine do not occur in mice – with or without co-administration of alcohol – after oral exposure to tartrazine.

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“…Mais il n'existerait finalement que peu de réaction allergique. La prévalence de l'allergie à la tartrazine est inférieure à 0,12 % dans la population générale [31]. Il n'y a pas de lien établi avec l'asthme [32] et il n'existe qu'une corrélation faible avec l'urticaire [33].…”

Section: Tartrazine (E102)unclassified

Allergie aux colorants alimentaires : une pathologie à évoquer avec parcimonie

Lemoine

Tounian

2018

Revue Française d'Allergologie

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New considerations regarding the risk assessment on Tartrazine

Cited by 83 publications

References 50 publications

Exposure estimate for FD&C colour additives for the US population

Exposure estimate for FD&C colour additives for the US population

Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

Allergie aux colorants alimentaires : une pathologie à évoquer avec parcimonie

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