New cryogels based on polymers and zeolite L for controlled Enalapril maleate release

Ipate, Alina Mirela; Hamciuc, Corneliu; Kalvachev, Yuri; Gherman, Simona; Ochiuz, Lăcrămioara

doi:10.1016/j.jddst.2018.02.008

Cited by 18 publications

(13 citation statements)

References 36 publications

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“…The prediction and correlation for the in vitro L-arginine release from the modified release hydrogels was done according to the method described by Ipate et al [17]. The experimental data from the in vitro drug release experiments were investigated using four predictable models: Zero-order, first-order kinetics, Higuchi and Korsmeyer–Peppas models [18].…”

Section: Methodsmentioning

confidence: 99%

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

et al. 2019

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Two natural polymers, i.e., cellulose and water soluble pullulan, have been selectively oxidized employing the TEMPO-mediated protocol, to allow the introduction of C6-OOH groups. Thereafter, the composite hydrogels of poly(vinyl alcohol) (PVA) and different content of the oxidized polysaccharides were prepared by the freezing/thawing method. The Fourier transform infrared spectroscopy (FTIR) has been used to discuss the degree of interaction between the hydrogels constituents into the physical network. The homogeneity of the prepared hydrogels as revealed by the SEM show an excellent distribution of the oxidized polysaccharides inside the PVA matrix. The samples exhibit self-healing features, since they quickly recover the initial structure after being subjected to a large deformation. The cell viability was performed for the selected hydrogels, all of them showing promising results. The samples are able to load L-arginine both by physical phenomena, such as diffusion, and also by chemical phenomena, when imine-type bonds are likely to be formed. The synergism between the two constituents, PVA and oxidized polysaccharides, into the physical network, propose these hydrogels for many other biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

et al. 2019

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“…The gel formation reaction occurs in the ULMP, and the solvent crystals formed under cryogenic conditions act as porogen leading to the porous morphology of the gel after being thawed 3 . Cryogels are receiving increasing attention in tissue engineering 4,5 drug delivery, 6,7 water remediation for heavy metal removal 8 and for dye removal 9,10 applications. The interconnected macroporous morphology of cryogels presents a significant advantage during adsorption of impurities from solution.…”

Section: Introductionmentioning

confidence: 99%

“…Even though cryogels of polysaccharides like hyalurunan 5 and dextran, 5 alginate, 26 and chitosan 27,28 have been studied, reports on PUL cryogels are only scarce and very recently reported in the literature 6,29 . PUL/poly(vinyl alcohol) composite cryogels were synthesized and characterized in those studies 8,29 .…”

Section: Introductionmentioning

confidence: 99%

Pullulan/poly(N‐vinylimidazole) cryogel: An efficient adsorbent for methyl orange

Hezarkhani

Ustürk

Özbilenler

et al. 2021

J of Applied Polymer Sci

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Pullulan/poly(N‐vinylimidazole) (PNVI) hybrid cryogels were synthesized under free radical polymerization and chemical crosslinking conditions in an alkaline, aqueous solution of pullulan (PUL), N‐vinylimidazole (NVI), ammonium persulfate and epicholorohydrin (ECH) at −18°C. PUL and PNVI cryogels alone were also synthesized under similar conditions. Optimum cryogel formation conditions were determined by considering product yields and gel fractions of the samples. The products were characterized by elemental analysis, FTIR‐ATR spectrometry, Thermal gravimetric analysis, and scanning electron microscopy (SEM) analyses. It has been found that PUL/PNVI hybrid samples bear improved physicochemical properties compared to ECH crosslinked PUL and PNVI samples alone. They act as hydrogels in aqueous medium reaching equilibrium swelling capacity values of the order of 600%. Dried PUL/PNVI cryogels show higher thermal stability than the dried cryogels of the parent polymers and maintain their physical integrity over a prolonged time period. Macroporous morphology was revealed by SEM analysis. Having 54.2 mg/g maximum equilibrium adsorption capacity in 200 ppm methyl orange solution and maintaining 95% of its adsorption capacity at the end of seven consecutive adsorption/desorption cycles, PUL/PNVI cryogel proved to be an efficient and durable dye adsorbent using methyl orange as the model compound in aqueous solution.

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“…These aqueous solutions after cooling and degassetion can be cryogelled under freezing-thawing conditions. During the freezing period the hydroxyl groups of the adjacent polymer chains will interact to form intra and intermolecular hydrogen bonds resulting in formation of crystallites [21][22][23][24][25]. Parameters that influence the cryogenic treatment are freezing, and thawing temperatures, and the number of cycles [13,[26][27][28][29][30].…”

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confidence: 99%

“…Taking into consideration their biocompatibility, drug compatibility, water solubility, film forming, good mechanical and swelling properties, the PVA cryogels have been studied as drug delivery systems in oral, transdermal, buccal, intramuscular, rectal routes of administration [23,24,27,28]. Degree of crystallinity plays a major role in controlling diffusion of the drug from cryogels which can be designed as matrix or reservoir for drug delivery.…”

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confidence: 99%

Preparation and Pharmaco-Mechanical Characterization of Ketoprofen- Polyvinyl Alcohol Cryogel for Medical Applications

Stamate¹,

Ochiuz²,

Timofte³

et al. 2019

Rev. Chim.

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Polyvinyl alcohol is a biocompatible polymer used very commonly both in pharmaceutical and medical fields. Being a water-soluble polymer, it is suitable for the manufacture of hydrogels as well as cryogels used for various medical applications. The present work describes the preparation, structural and physico-mechanical characterization of polyvinyl alcohol cryogels loaded with ketoprofen. By cryogenic technique the polymeric solutions are transformed under certain conditions into porous, elastic and very compressible structures. They are able to absorb a large amount of liquids that they give off by gentle compression. The prepared cryogels were evaluated for different physical, chemical and structural properties, as following: internal morphology, equilibrium swelling ratio and mechanical testing. The cryogel structures show good elasticity and optimal swelling at different temperatures. Due to these properties the studied cryogels are suitable for use in various medical applications involving liquid absorption, mechanical resistance and anti-inflammatory effect.

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New cryogels based on polymers and zeolite L for controlled Enalapril maleate release

Cited by 18 publications

References 36 publications

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications

Pullulan/poly(N‐vinylimidazole) cryogel: An efficient adsorbent for methyl orange

Preparation and Pharmaco-Mechanical Characterization of Ketoprofen- Polyvinyl Alcohol Cryogel for Medical Applications

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