New data on the cytolytic effects of natural killer cells (Kurloff cells) on a leukemic cell line (guinea pig L2C)

Debout, Claire; Quillec, M.; Izard, Juan Francisco Martín

doi:10.1016/s0145-2126(98)00155-6

Cited by 14 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The only statistically significant difference between groups was an increased proportion of neutrophils at day 2 for P18-infected guinea pigs compared with mockinfected guinea pigs (P2532.6±11.7 %; P18537.1±14.3 %; mock516.1±7.7 %). We did not identify any cells with the characteristic morphology of the NK-like Kurloff cells in peritoneal cell populations from any group (Debout et al, 1993). Cytokine mRNA levels in the spleen and liver at mid-late stage infection…”

Section: Cytokine Patterns From Peritoneal Cells Early In Infectionmentioning

confidence: 76%

Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs

Scott

Aronson

2008

Journal of General Virology

View full text Add to dashboard Cite

Arenaviruses such as Lassa virus cause a spectrum of disease in humans ranging from mild febrile illness to lethal haemorrhagic fever. The contributions of innate immunity to protection or pathogenicity are unknown. We compared patterns of expression of cytokines of innate immunity in mild versus severe arenavirus disease using an established guinea pig model based on the macrophage-tropic arenavirus Pichinde virus (PICV). Cytokine transcripts were measured by using real-time RT-PCR in target organs and blood during mild infection (caused by PICV, P2 variant) and lethal haemorrhagic fever (caused by PICV, P18 variant). In the initial peritoneal target cells, virulent P18 infection was associated with significantly increased gamma interferon (IFN-γ) and monocyte chemoattractant protein-1 (MCP-1, CCL2) mRNA levels relative to P2 infection. Peritoneal cells from P18-infected animals had decreased tumour necrosis factor alpha (TNF-α), interleukin (IL)-8 (CXCL-8) and IL-12p40 transcripts relative to mock-infected animals. Late in infection, P18-infected peripheral blood leukocytes (PBL) had decreased TNF-α, IFN-γ, and regulated upon activation, normal T cell expressed and secreted (RANTES, CCL-5) cytokine transcripts relative to P2-infected PBL. We conclude that, in severe arenavirus disease, patterns of cytokine expression in the initially infected cells favour recruitment of additional target monocytes, while inhibiting some of their pro-inflammatory responses. Suppression rather than overexpression of pro-inflammatory cytokines accompanied the terminal shock in this model of arenavirus haemorrhagic fever.

show abstract

Section: Cytokine Patterns From Peritoneal Cells Early In Infectionmentioning

confidence: 76%

Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs

Scott

Aronson

2008

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…Macrophages act as the primary effector cells for the early clearance of mycobacteria. Both CD4 + and CD8 + T cells are known to mediate the immune response against M. tuberculosis but other cell types, including natural killer (NK) cells, are also involved [10–12]. Both interferon (IFN)‐γ and tumour necrosis factor (TNF)‐α have been identified as important cytokines for the effector functions against mycobacteria [13,14].…”

Section: Introductionmentioning

confidence: 99%

Lung macrophages from bacille Calmette–Guérin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth ofM. tuberculosisafter recombinant guinea pig interferon-γ activation

Jeevan

Majorov

Sawant

et al. 2007

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryThe guinea pig model of low-dose pulmonary tuberculosis has been used to study the pathogenesis of infection as well as the mechanisms of bacille Calmette-Guérin (BCG) vaccine-induced resistance. We investigated the function of lung cells from naive and BCG-vaccinated guinea pigs after enzymatic digestion of lung tissue with collagenase and DNase I. The total lung digest cells proliferated poorly to purified protein derivative (PPD) but comparatively better to ConA as assessed by

show abstract

“…We suggest that TCR/MHC localization is an important element in the regulation of the efficiency of T cell activation. The second aspect discussed in detail is cell couple dynamics, that is the formation, the tightness, and the maintenance of a cellular interface, in NK cell/target cell interactions (29–33). As opposed to T cell/APC interactions, NK cell/target cell couples are often tentative.…”

Section: Introductionmentioning

confidence: 99%

Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance

Wülfing¹,

Tskvitaria-Fuller²,

Burroughs³

et al. 2002

Immunological Reviews

View full text Add to dashboard Cite

Cellular interaction is vital to the activation of most lymphocytes. At the interface between the lymphocyte and the cell that activates it, multiple receptor/ligand pairs accumulate in distinct patterns. This accumulation is intriguing, as it is likely to shape the quality of receptor signaling and thereby lymphocyte behavior. Here we address such receptor/ligand accumulation with an emphasis on T and natural killer (NK) cells. First, we discuss the strengths and limitations of commonly used approaches to visualize receptor/ligand accumulation. Second, we discuss two principal mechanisms of receptor and ligand translocation, diffusion and cytoskeletal transport, as understanding these mechanisms can be invaluable in the determination of the significance of receptor/ligand accumulation. We show that the extent of receptor/ligand accumulation at the T cell/antigen presenting cell interface is dominated by diffusion for all but the lowest affinity interactions, while patterning of these receptors/ligands within the interface is strongly influenced by cytoskeletal transport. Third, we discuss two specific issues in lymphocyte receptor/ligand accumulation. We review the abundant but frequently controversial data on T cell receptor (TCR)/major histocompatibility complex (MHC) accumulation and suggest that central TCR/MHC accumulation is a mediator of efficient T cell activation. In the investigation of NK cell/target cell interactions, we characterize the often tentative NK cell/target cell couple maintenance, as it creates a major obstacle in studying receptor/ligand accumulation.

show abstract

New data on the cytolytic effects of natural killer cells (Kurloff cells) on a leukemic cell line (guinea pig L2C)

Cited by 14 publications

References 32 publications

Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs

Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs

Lung macrophages from bacille Calmette–Guérin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth ofM. tuberculosisafter recombinant guinea pig interferon-γ activation

Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance

Contact Info

Product

Resources

About