New developments about the association of SV40 with human mesothelioma

Carbone, Michele; Pass, Harvey I.; Miele, Lucio; Bocchetta, Maurizio

doi:10.1038/sj.onc.1206552

Cited by 86 publications

(63 citation statements)

References 44 publications

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“…A few studies have reported SV40 Tag expression by immunohistochemistry in mesothelioma. 1 Global techniques such as PCR may detect DNA sequences from bystander SV40-positive cells, but if we consider SV40 to have a significant role in human oncogenesis, the genome and its gene products must be detected within tumor cells. In the recent report by MacKenzie et al, 4 none of the 152 cases of NHL scored positively for SV40.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Brousset

Araujo

Gascoyne

2004

Intl Journal of Cancer

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DNA sequences from simian virus 40 (SV40) have been detected in various human tumors, including non-Hodgkin's lymphomas (NHLs), by highly sensitive PCR techniques. However, there is a strong debate as to whether SV40 is present in lymphoma cells. Using immunohistochemistry and tissue microarrays, we investigated a series of French and Canadian cases of Hodgkin's lymphomas (HLs) and NHLs and tried to detect the SV40 large T antigen using routine paraffin sections with standard and highly sensitive catalyzed system amplification methods. None of the cases of HLs (n ‫؍‬ 250) or NHLs (n ‫؍‬ 232) were found to contain a single large T antigen-positive cell, whereas 2 positive controls were repeatedly stained. Therefore, our results do not support the hypothesis that SV40 is implicated in the etiology of human lymphomas.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Brousset

Araujo

Gascoyne

2004

Intl Journal of Cancer

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“…However, the discovery of a viral implication in CNS tumorigenesis may open different ways for preventing tumours with a constant fatal outcome such as glioblastomas. Accumulating data seem to indicate that SV40 is implicated in different tumours in humans and in particular in central nervous system (CNS) (Bergsagel et al, 1992;Klein et al, 2002;Carbone et al, 2003;Vilchez and Butel, 2003) However, there are strong controversies as to whether SV40 is directly linked to cancer development and a consensus is far from being reached in particular in lymphoma (Shivapurkar et al, 2002;Vilchez et al, 2002;Capello et al, 2003;MacKenzie et al, 2003).…”

mentioning

confidence: 99%

Detection of human cytomegalovirus genome and gene products in central nervous system tumours

et al. 2005

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Human cytomegalovirus (HCMV) genome and related proteins have been reported in a great proportion of malignant gliomas. However, these results are unexpected since HCMV is not known as an oncogenic virus. By immunohistochemistry (with an anti-IE1 monoclonal antibody) and in situ hybridisation (with biotinylated DNA probes) on tissue microarrays and frozen sections, we investigated a French series of central nervous system (CNS) tumours, including 97 glioblastomas. In 10 cases of glioblastoma, rare astrocyte-like cells, admixed with tumour cells, stained positively for HCMV and in one case a doubtful staining of rare cells was noticed. This may indicate a reactivation of the virus under local immunosuppression but none of the cases of CNS tumours (n ¼ 132) contained HCMV genomes and/or proteins in a significant proportion of tumour cells. Our results strongly suggest that HCMV is unlikely to be implicated in the development of human malignant gliomas, at least in French cases.

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“…10 -12 Human mesothelial cells are unusually susceptible to SV40 infection compared with fibroblasts. [3][4][5] In mesothelial cells, Tag binds p53 and inhibits its tumor suppressor activity. At the same time, the interaction inhibits the ability of the virus to replicate, which ultimately leads to prolonged exposure of the cell to the mutagenic effects of Tag.…”

Section: Sv40mentioning

confidence: 99%

“…The modes by which the virus was transferred from monkey to human are uncertain, but it is possible that the bulk of this transfer may have occurred from 1954 to 1963 through SV40-contaminated polio vaccines administered worldwide. 3 SV40 can be excreted via human feces, breast milk, and semen 4 , and Butel et al 5 and Butel and Lednicky 6 have reported that 5.9% of 377 Texas children born between 1980 and 1995 had SV40-neutralizing antibodies.…”

Section: Sv40mentioning

confidence: 99%

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Evolving Aspects of Mesothelioma Carcinogenesis: SV40 and Genetic Predisposition

Carbone

Pass

2006

Journal of Thoracic Oncology

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M alignant mesothelioma is characterized by a long latency from the time of exposure to asbestos to the onset of disease, which suggests that multiple somatic genetic events are required for tumorigenic conversion of a normal mesothelial cell. Epidemiological studies have established that exposure to asbestos fibers is the primary cause of malignant mesothelioma 1,2 , and recent investigations have implicated simian virus 40 (SV40) and genetic predisposition in the etiology of some malignant mesothelioma. SV40SV40 is a DNA tumor virus that is endogenous in rhesus monkeys and is now widespread among the human population. The modes by which the virus was transferred from monkey to human are uncertain, but it is possible that the bulk of this transfer may have occurred from 1954 to 1963 through SV40-contaminated polio vaccines administered worldwide. 3 SV40 can be excreted via human feces, breast milk, and semen 4 , and Butel et al. 5 and Butel and Lednicky 6 have reported that 5.9% of 377 Texas children born between 1980 and 1995 had SV40-neutralizing antibodies. SV40 produces two oncogenic proteins, the large and small t antigens. 2,4 The large T antigen (Tag) is capable of inducing structural and numerical chromosomal alterations. Tag also induces insulin-like growth factor expression and inhibits p53 and the pRb family, and it induces c-met activity to stimulate cell proliferation. 3,4 The small t antigen (tag) inhibits cellular phosphatase 2A, stimulates MAP kinase and AP-1 activity, and works with Tag to bind and inhibit p53 and pRb. 3 The combined activity of both the large Tag and the small tag induce Notch-1 and telomerase activity, which are required for malignant transformation and immortalization. 7,8 Analysis of human mesotheliomas for the virus revealed that SV40 sequences were present in 29 of 48 human mesothelioma samples (60%). Sequence analysis confirmed that the virus detected was SV40. 9 Polymerase chain reaction analysis, mRNA in situ hybridization, microdissection, and immunostaining techniques used in several studies have also shown that SV40 sequences and antigens are found in tumor cells but not in the normal adjacent tissue. 2,4 Although more than 60 laboratories have found SV40 in human mesotheliomas and other tumors, the virus was not detected in Finnish, Austrian, and Turkish mesothelioma specimens, 2-4 which suggests that the presence of SV40 in human tumors may be influenced by geographic factors. One of these factors may be related to polio vaccine distribution, because SV40-contaminated polio vaccines were not administered in Finland, Austria, and Turkey. 2,3 Three independent panels have reviewed and confirmed the association of SV40 with human tumors, especially mesothelioma. 10 -12 Human mesothelial cells are unusually susceptible to SV40 infection compared with fibroblasts. [3][4][5] In mesothelial cells, Tag binds p53 and inhibits its tumor suppressor activity. At the same time, the interaction inhibits the ability of the virus to replicate, which ultimately leads to prolonge...

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New developments about the association of SV40 with human mesothelioma

Cited by 86 publications

References 44 publications

Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Detection of human cytomegalovirus genome and gene products in central nervous system tumours

Evolving Aspects of Mesothelioma Carcinogenesis: SV40 and Genetic Predisposition

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