New Developments and Novel Therapeutic Perspectives for Vitamin C ,

Abstract

Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements. However, to function effectively as an antioxidant (or a pro-oxidant), relatively high levels of this vitamin must be maintained in the body. The instability of vitamin C combined with its relatively poor intestinal absorption and ready excretion from the body reduce physiological availability of this vitamin. This inability to maintain high serum levels of vitamin C may have serious health implications and is particularly relevant in the onset and progression of degenerative disease, such as cancer and cardiovascular disease (CVD), which have a strong contributing oxidative damage factor. In this review, we examine recent studies on the regulation of transport mechanisms for vitamin C, related clinical ramifications, and potential implications in high-dose vitamin C therapy. We also evaluate recent clinical and scientific evidence on the effects of this vitamin on cancer and CVD, with focus on the key mechanisms of action that may contribute to the therapeutic potential of this vitamin in these diseases. Several animal models that could be utilized to address unresolved questions regarding the feasibility of vitamin C therapy are also discussed.

Microbiological and Some Sensory Attributes of Water Melon Juice and Watermelon-orange Juice Mix

“…Vitamin C loss is known to increase with exposure to heat (as in pasteurization), light and oxygen. Vitamin C is involved in protein metabolism, collagen synthesis and an important physiological antioxidant (Li and Schellhorn, 2007). It also plays an important role in immune function, improves absorption of non-heme iron and participates in biosynthesis of glucocorticoids (Gershoff, 1993).…”

Antioxidants in Wild Mushrooms

“…Vitamin C is effective against superoxide, hydroxyl radical, hydrogen peroxide, peroxyl radical and singlet oxygen [118]. Cooperative interactions exist among vitamin C and vitamin E. They interact synergistically at the membrane-cytosol interface to regenerate membrane-bound oxidized vitamin E [119] (Fig. 2).…”

El Consumo De Frutas Y Hortalizas Ayuda a Prevenir El Daño Endotelial

“…Acción de antioxidantes Vitamina C y E. La vitamina C mejora la disfunción endotelial (108), estabilizando la tetrahidrobiopterina, cofactor de la eNOS, aumentando la biodisponibilidad de NO (109,110). Además, junto a la vitamina E protege al NO bloqueando a las ROS, actuando sobre los receptores de angiotensina II e indirectamente estimulando la síntesis de prostaglandina I2 (PGI2) (111)(112)(113).…”