2001
DOI: 10.1254/fpj.117.49
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New Developments in Drug Dependence Studies. Animal models of drug dependence using the drug self-administration method.

Abstract: This paper will review 1) experimental models of drug-seeking behavior and 2) mechanisms underlying the behavior, focusing on cocaine self-administration. After the acquisition of self-administration, vigorous lever-pressing is generally observable after the drug was replaced by saline. This lever-pressing behavior under saline infusion can be considered "drug-seeking behavior". Drug-seeking behavior is reinstated by non-contingent injection of the drug, stress exposure and presentation of drug-associated stim… Show more

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Cited by 2 publications
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