New developments in optical coherence tomography

Kostanyan, Tigran; Wollstein, Gadi; Schuman, Joel S.

doi:10.1097/icu.0000000000000133

Cited by 40 publications

(34 citation statements)

References 45 publications

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“…Mostly applied in ophthalmology, OCT provides 3D images of tissue structures with micrometer scale resolution and rapid imaging speeds on the order of a few seconds per volume24. However, OCT has also been used for 3D imaging of brain tissue.…”

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confidence: 99%

Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

Baumann

Wöehrer

Ricken

et al. 2017

Sci Rep

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One major hallmark of Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (Aβ). In AD, degeneration of neurons is preceded by the formation of Aβ plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature neuritic Aβ plaques based on their birefringent properties. Formalin-fixed, post-mortem brain samples of advanced stage AD patients were investigated. In several cortical brain regions, neuritic Aβ plaques were successfully visualized in tomographic and three-dimensional (3D) images. Cortical grey matter appeared polarization preserving, whereas neuritic plaques caused increased phase retardation. Consistent with the results from PS-OCM imaging, the 3D structure of senile Aβ plaques was computationally modelled for different illumination settings and plaque sizes. Furthermore, the birefringent properties of cortical and meningeal vessel walls in CAA were investigated in selected samples. Significantly increased birefringence was found in smaller vessels. Overall, these results provide evidence that PS-OCM is able to assess amyloidosis based on intrinsic birefringent properties.

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confidence: 99%

Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

Baumann

Wöehrer

Ricken

et al. 2017

Sci Rep

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“…AO corrects for the monochromatic optical aberrations of the eye, thus improving the resolution of ocular imaging technologies (49). For example, AO-OCT improves transverse resolution from the typical 20μm to approximately 5μm (50).…”

Section: Novel Oct Technologies and Applicationsmentioning

confidence: 99%

The Future of Imaging in Detecting Glaucoma Progression

et al. 2017

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Ocular imaging has been heavily incorporated into glaucoma management and provides important information that aids in the detection of disease progression. Longitudinal studies have shown that the circumpapillary retinal nerve fiber layer is an important parameter for glaucoma progression detection, while other studies demonstrated that macular parameters, such as the ganglion cell inner plexiform layer and optic nerve head parameters are also useful for progression detection. The introduction of novel technologies with faster scan speeds, wider scanning fields, higher resolution, and improved tissue penetration has enabled the precise quantification of additional key ocular structures, such as the individual retinal layers, optic nerve head, choroid, and lamina cribrosa. Furthermore, extracting functional information from scans such as blood flow rate and oxygen consumption provides new perspectives on the disease and its progression. These novel methods promise improved detection of glaucoma progression and better insight into the mechanisms of progression that will lead to better targeted treatment options to prevent visual damage and blindness.

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“…Esta tecnología puede distinguir estructuras oculares basándose en propiedades que alteran la polarización. Podría ser útil para la detección precoz el glaucoma, ya que hay estudios que sugieren que cambios en la polarización de la capa de fibras nerviosas preceden a la disminución de espesor, o bien, para estimar de forma no invasiva la fibrosis en la ampolla de cirugías filtrantes, usando un PS-OCT de segmento anterior, por citar algunos ejemplos de su aplicación clínica 3 .…”

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“…Otro avance interesante en la OCT es la incorporación de Adaptive Optics-OCT (AO-OCT), que aporta mejoría de la resolución transversal, de 1 a 5 7 , corrigiendo las aberraciones ópticas que se producen cuando el haz de luz pasa por diferentes medios ópticos, con lo cual se consigue la adquisición de imágenes de alta calidad, que permiten la visualización de detalles finos, como la microvasculatura retiniana, los fotorreceptores, la lámina cribosa y microestructuras dentro de la capa de fibras nerviosas y la capa de células ganglionares, casi a nivel celular 3 .…”

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