New developments in the diagnosis and characterization of Waldenström’s macroglobulinemia

García-Sanz, Ramón; Hunter, Zachary R.; Poulain, Stéphanie; Varettoni, Marzia; Owen, Roger G.

doi:10.1080/17474086.2023.2270779

Expert Review of Hematology

2023

DOI: 10.1080/17474086.2023.2270779

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New developments in the diagnosis and characterization of Waldenström’s macroglobulinemia

Ramón García-Sanz,

Zachary R. Hunter,

Stéphanie Poulain

et al.

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2024

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Cited by 7 publications

References 106 publications

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Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

Østergaard,

Munksgaard,

Nielsen

et al. 2024

eJHaem

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Introduction: Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood. Methods: In this single‐center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients. Results: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively. Conclusion: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long‐term survival.

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Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

Østergaard,

Munksgaard,

Nielsen

et al. 2024

eJHaem

View full text Add to dashboard Cite

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Impact of the presence and number of chromosomal abnormalities on the clinical outcome in Waldenström Macroglobulinemia: a monocentric experience

Danesin,

Bonaldi,

Martines

et al. 2024

Ann Hematol

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The prognostic and predictive role of specific gene mutations in Waldenström Macroglobulinemia (WM) is well-ascertained whereas the clinical impact of chromosome aberrations is far less known. Recent work has provided initial evidence for an adverse prognostic impact of some aberrations, such as del(6q), while other studies suggest a possible relationship between some clinical features (e.g. advanced age and/or inflammatory status) and specific cytogenetic abnormalities. To add to the still limited knowledge on WM cytogenetics and its clinical implications, we herein report our experience in a cohort of WM patients across 23 years. Based on our retrospective study, we found that abnormal karyotype was more represented in older patients and maintained a statistically significant independence from other molecular, clinical, and biological features related to WM. The presence and number of cytogenetic aberrations correlated with inferior overall and progression-free survival outcomes regardless of the type of single chromosome aberration. Our data suggests that the role of the altered karyotype deserves to be further clarified especially in elderly WM patients, in whom cytogenetic abnormalities and disease biology appear to be characterized by a higher degree of complexity.

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Cold-antibody Autoimmune Hemolytic Anemia: its Association with Neoplastic Disease and Impact on Therapy

Berentsen

2024

Curr Oncol Rep

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New developments in the diagnosis and characterization of Waldenström’s macroglobulinemia

Cited by 7 publications

References 106 publications

Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

Impact of the presence and number of chromosomal abnormalities on the clinical outcome in Waldenström Macroglobulinemia: a monocentric experience

Cold-antibody Autoimmune Hemolytic Anemia: its Association with Neoplastic Disease and Impact on Therapy

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