New Dihydrochalcone and Propenamide from Lithocarpus polystachyus

Abstract

Two new compounds, (E)-4-(3, 4-dihydroxyphenyl)-N-(1-hydroxy-2-(4-hydroxyphenyl) ethyl)-2-oxobut-3-enamide (1) and phloretin2-O--D-apiofuranosyl (16)--D-glucopyranoside (2) were isolated from Lithocarpus polystachyus Rehd. Their structures were determined on the basis of analysis of their 1D and 2D NMR spectroscopic and mass spectral data.

The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects ofLithocarpus polystachyus(sweet tea) on APAP-induced oxidative stress injury in mice

“…is mainly distributed in wild mountainous terrain which is rich in plant resources. 10,11 It has the popular name "sweet tea" (ST) in folk medicine and serves as a traditional herbal medicine against various diseases. [12][13][14] The tender leaves of L. polystachyus have been used as a traditional Chinese herb and a sweet tonic drink for several hundreds of years in southern China.…”

Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice

“…Lithocarpus polystachyus Rehd (LPR, Figure A), also known as sweet tea, is an evergreen tree of the genus Quercus in the family Fagaceae. LPR is a common tea beverage and folk health care product in southwest China with rich flavonoids and tea polyphenols and has a high application value in the fields of new drugs and functional foods. − Trilobatin (TLB, Figure B), a strong natural sweetener, is a novel glycosylated dihydrochalcone isolated from the leaves of LPR and has been reported to have antioxidant properties …”