New Dihydroxytyrosyl Esters from Dicarboxylic Acids: Synthesis and Evaluation of the Antioxidant Activity In Vitro (ABTS) and in Cell-Cultures (DCF Assay)

Roma, Elia; Mattoni, Elena; Lupattelli, Paolo; Moeini, Seyed Sepehr; Gasperi, Tecla; Bernini, Roberta; Incerpi, Sandra; Tofani, Daniela

doi:10.3390/molecules25143135

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…44 In the study, the scavenging ability of TUR on ABTS•+ radicals and the protective effect on H 2 O 2 -induced PC12 cell oxidative damage were investigated to explore whether TUR had a similar or better antioxidant capacity and neuroprotective effects than those of CU. 45,46 The results revealed that TUR had a more substantial antioxidant capacity than CU or ascorbic acid. However, neither CU nor TUR significantly improved cell survival in a cell injury model.…”

Section: Discussionmentioning

confidence: 95%

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect

Sheng,

Wei,

et al. 2023

IJN

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The early stage of this study verified that a turmeric extract (TUR) including 59% curcumin (CU), 22% demethoxycurcumin (DMC), and 18% bisdemethoxycurcumin (BDMC), could enhance the stability of CU and had greater antidepressant potential in vitro. The objective of the study was to develop a nano-delivery system containing TUR (TUR-NE) to improve the pharmacokinetic behavior of TUR and enhance its antidepressant effect. Methods: The antidepressant potential of TUR was explored using ABTS, oxidative stress-induced cell injury, and a high-throughput screening model. TUR-NE was fabricated, optimized and characterized. The pharmacokinetic behaviors of TUR-NE were evaluated following oral administration to normal rats. The antidepressant effect of TUR-NE was assessed within chronic unpredictable mild stress model (CUMS) mice. The behavioral and biochemical indexes of mice were conducted. Results:The results depicted that TUR had 3.18 and 1.62 times higher antioxidant capacity than ascorbic acid and CU, respectively. The inhibition effect of TUR on ASP+ transport was significantly enhanced compared with fluoxetine and CU. TUR-NE displayed a particle size of 116.0 ± 0.31 nm, polydispersity index value of 0.121 ± 0.007, an encapsulation rate of 98.45%, and good release and stability in cold storage. The results of pharmacokinetics indicated the AUC (0-t) of TUR-NE was 8.436 and 4.495 times higher than that of CU and TUR, while the C max was 9.012 and 5.452 times higher than that of CU and TUR, respectively. The pharmacodynamic study confirmed that the superior antidepressant effect of TUR-NE by significantly improving the depressant-like behaviors and elevating the content of 5-hydroxytryptamine in plasma and brain in CUMS mice. TUR-NE showed good safety with repeated administration. Conclusion: TUR-NE, which had small and uniform particle size, enhanced the bioavailability and antidepressant effect of TUR. It could be a promising novel oral preparation against depression.

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Section: Discussionmentioning

confidence: 95%

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect

Sheng,

Wei,

et al. 2023

IJN

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“…Synthetic procedures have been also optimized to improve the bioavailability of HTyr and OLE. Lipophilic derivatives [ 57 , 58 , 59 , 60 , 61 ] and novel compounds were synthetized without modifying the catecholic moiety to be tested in vitro and in vivo as antioxidant, anticancer, anti-inflammatory, and neuroprotective agents [ 62 , 63 , 64 , 65 ]. Emerging research is devoted to developing drug delivery systems based on liposomes [ 66 ] and nanotechnology [ 67 ] for a better bioavailability and improved biological activities of both HTyr and OLE [ 68 ].…”

Section: Chemistry Of Hydroxytyrosol (Htyr) and Oleuropein (Ole)mentioning

confidence: 99%

Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

et al. 2023

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Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with a gradual reduction of physiological activities in cells and organs. This degeneration results in a reduced ability to adapt to homeostasis perturbations and an increased incidence of illnesses such as cognitive decline, neurodegenerative and cardiovascular diseases, cancer, diabetes, and skeletal muscle pathologies. Key features of aging include a chronic low-grade inflammation state and a decrease of the autophagic process. The Mediterranean diet has been associated with longevity and ability to counteract the onset of age-related disorders. Extra virgin olive oil, a fundamental component of this diet, contains bioactive polyphenolic compounds as hydroxytyrosol (HTyr) and oleuropein (OLE), known for their antioxidant, anti-inflammatory, and neuroprotective properties. This review is focused on brain, skeletal muscle, and gut microbiota, as these systems are known to interact at several levels. After the description of the chemistry and pharmacokinetics of HTyr and OLE, we summarize studies reporting their effects in in vivo and in vitro models of neurodegenerative diseases of the central/peripheral nervous system, adult neurogenesis and depression, senescence and lifespan, and age-related skeletal muscle disorders, as well as their impact on the composition of the gut microbiota.

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“…A few works evaluated the overall flavonoid content by colorimetric assays in dried bulbs of Allium ursinum L. [ 113 ] and leaves of Rosmarinus officinalis L. [ 101 ] and Camellia sinensis L. [ 100 ]. The significative antioxidant power of polyphenols is strictly related to the presence of a catechol or pyrogallol moiety in the aromatic ring [ 203 , 207 , 208 , 209 ]. Iniguez-Franco et al reported a positive antioxidant performance from PLA functionalized with catechin or epicatechin by extrusion [ 107 ].…”

Section: Active Pla-based Materialsmentioning

confidence: 99%

Natural Active Ingredients for Poly (Lactic Acid)-Based Materials: State of the Art and Perspectives

et al. 2022

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This review describes the state of the art in the field of poly (lactic acid) (PLA)-based materials activated by natural compounds and extracts (active ingredients, AIs) from plant sources for food and biomedical applications. With a multidisciplinary approach, after a description of the synthesis and properties of PLA, special attention was paid to the chemical properties and unconventional extraction technologies of AIs used for PLA activation. Innovative techniques for the incorporation of AIs into PLA; characterization and the antioxidant and antimicrobial properties of the novel materials were discussed. In view of future perspectives, this study has evidenced that some aspects need to be further investigated from joint research between academia and industry, according to the green chemistry principles and circular economy strategy.

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New Dihydroxytyrosyl Esters from Dicarboxylic Acids: Synthesis and Evaluation of the Antioxidant Activity In Vitro (ABTS) and in Cell-Cultures (DCF Assay)

Cited by 5 publications

References 34 publications

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect

Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

Natural Active Ingredients for Poly (Lactic Acid)-Based Materials: State of the Art and Perspectives

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