New Dimeric Morphine from Opium Poppy (Papaver somuniferum) and Its Physiological Function

Morimoto, Satoshi; Suemori, Kazunari; Taura, Futoshi; Shoyama, Yukihiro

doi:10.1021/np020583l

Cited by 17 publications

(4 citation statements)

References 11 publications

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“…Bismorphine could be so evaluated as a defence response of the opium poppy. Morimoto et al (2003) together with bismorphine A identified also bismorphine B in the wounded capsules of Papaver somniferum.…”

mentioning

confidence: 84%

Relations among alkaloids, cadmium and zinc contents in opium poppy (Papaver somniferum L.)

Lachman¹,

Hejtmánková²,

Miholová³

et al. 2006

PLANT SOIL ENVIRON

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The effort of this work was to prove whether there exists any relation between stress factors caused by content of cadmium and zinc, and content and composition of opium alkaloids codeine, morphine, narcotine (noscapine) and papaverine contained in poppy seeds and capsules (Papaver somniferum L.) in 14 samples of 8 varieties cultivated in 8 localities in 2003. Contents of cadmium and zinc were measured by a method of electrothermic atomization and contents of selected individual alkaloids were determined by a HPLC method. The results were tested by the Spearman correlation coefficient and the Pearson linear correlation coefficient. With knowledge of the Spearman coefficient, positive relations narcotine -zinc and narcotine -cadmium in the poppy seed samples were found. In the samples of poppy capsules positive relation morphine -cadmium (in cv. Opal) and negative relation papaverine -zinc and codeine -zinc (in cv. Opal) were found. Those pairs have been tested by the Pearson correlation coefficient for a possibility to exclude the linear independency. This independency was excluded with the probability of over 95% in the relations narcotine -cadmium in the seeds and morphine -cadmium in the capsules. With the probability of over 97.5%, linear relations narcotine -zinc in seeds and papaverine -zinc in capsules were proved.

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mentioning

confidence: 84%

Relations among alkaloids, cadmium and zinc contents in opium poppy (Papaver somniferum L.)

Lachman¹,

Hejtmánková²,

Miholová³

et al. 2006

PLANT SOIL ENVIRON

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“…Host plants thicken their cell walls by producing large amounts of HCAAs, such as feruloyltyramine and feruloylputrescine, to prevent the spread of disease (Pushpa et al, 2014;Yogendra et al, 2014). Other chemical groups, such as benzylisoquinoline, flavonoid glycosides, and fatty acids, also play crucial roles in cell wall thickening (Morimoto et al, 2003;Franke et al, 2012;Gunnaiah et al, 2012), thus forming a physical barrier against P. infestans infection (Yogendra et al, 2015). Over the past two decades, significant efforts have also been undertaken to determine the metabolomic responses of potatoes to the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and Phytophthora infestans

et al. 2022

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Late blight is one of the main biological stresses limiting the potato yield; however, the biochemical mechanisms underlying the infection process of Phytophthora infestans remain unrevealed. In this study, the late blight-resistant potato cultivar Ziyun No.1 (R) and the susceptible cultivar Favorita (S) were inoculated with P. infestans. Untargeted metabolomics was used to study the changes of metabolites in the compatible and incompatible interactions of the two cultivars and the pathogen at 0, 48, and 96 h postinoculation (hpi). A total of 819 metabolites were identified, and the metabolic differences mainly emerged after 48 hpi. There were 198 and 115 differentially expressed metabolites (DEMs) in the compatible and incompatible interactions. These included 147 and 100 upregulated metabolites during the compatible and incompatible interactions, respectively. Among them, 73 metabolites were identified as the P. infestans-responsive DEMs. Furthermore, the comparisons between the two cultivars identified 57 resistance-related metabolites. Resistant potato cultivar had higher levels of salicylic acid and several upstream phenylpropanoid biosynthesis metabolites, triterpenoids, and hydroxycinnamic acids and their derivatives, such as sakuranetin, ferulic acid, ganoderic acid Mi, lucidenic acid D2, and caffeoylmalic acid. These metabolites play crucial roles in cell wall thickening and have antibacterial and antifungal activities. This study reports the time-course metabolomic responses of potatoes to P. infestans. The findings reveal the responses involved in the compatible and incompatible interactions of potatoes and P. infestans.

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“…Some dimeric morphine substances have been found in opium poppies using HPLC [17] and their physiological function in the poppies was discussed.…”

Section: Plant Materialsmentioning

confidence: 99%

Sample preparation and separation techniques for bioanalysis of morphine and related substances

Hansen

2009

J of Separation Science

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In present time the use or misuse of morphine and its derivatives are monitored by assaying the presence of the drug and its metabolites in biofluids. In the present review, focus is placed on the sample preparation and on the separation techniques used in the current best practices of bioanalysis of morphine and its major metabolites. However, as methods for testing the misuse of heroin, a morphine derivative, often involve bioanalytical methods that cover a number of other illicit drug substances, such methods are also included in the review. Furthermore, the review also includes bioanalysis in a broader perspective as analysis of plant materials, cell cultures and environmental samples. The review is not intended to cover all publications that include bioanalysis of morphine but is more to be considered a view into the current best practices of bioanalysis of morphine, its metabolites and other related substances.

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New Dimeric Morphine from Opium Poppy (Papaver somuniferum) and Its Physiological Function

Cited by 17 publications

References 11 publications

Relations among alkaloids, cadmium and zinc contents in opium poppy (Papaver somniferum L.)

Relations among alkaloids, cadmium and zinc contents in opium poppy (Papaver somniferum L.)

Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and Phytophthora infestans

Sample preparation and separation techniques for bioanalysis of morphine and related substances

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