New dinuclear palladium(II) complexes with benzodiazines as bridging ligands: interactions with CT-DNA and BSA, and cytotoxic activity

Franich, Andjela A.; Živković, Marija D.; Ćoćić, Dušan; Petrović, Biljana; Milovanović, Marija; Arsenijević, Aleksandar; Milovanović, Jelena; Arsenijević, Dragana; Stojanović, Bojana; Djuran, Miloš I.; Rajković, Snežana

doi:10.1007/s00775-019-01695-w

Cited by 32 publications

(22 citation statements)

References 46 publications

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“…10) and results suggest that complex quenches intrinsic uorescence of BSA. Value of K sv , binding constant (K a ), and binding sites (n) are in range of 1.07-2.80 × 10 3 M − 1 , 0.10-0.58 × 10 5 M − 1 , and 0.92-1.12, respectively which is comparable with reported literature [36,37]. The order of binding constant K a of pyrazole-based palladium(II) complexes: I < VI < II < V < IV < III.…”

Section: Molecular Docking Studysupporting

confidence: 89%

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Patel

Dhaduk

Dabhi

et al. 2021

Preprint

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A series of trisubstituted pyrazole-based ligands (L1-L6) and corresponding palladium(II) complexes were synthesized and characterized by conductivity measurement, 1H NMR, 13C NMR, Fourier Transform infrared (FT-IR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Synthesized compounds were screened for various biological activities. UV-Vis spectroscopy, viscosity measurement, fluorescence spectroscopy and molecular docking studies were used to determine the binding mode between HS-DNA and complexes, which suggest intercalation mode of binding. The protein binding study of complexes was evaluated by UV-visible spectroscopy. Antibacterial study of the complexes was screened against two Gram (+ve) and three Gram (-ve) bacteria and results show that all complexes are more effective against microorganisms than their respective ligands. The cytotoxicity of the synthesized compounds was tested against brine shrimp and MCF-7 Cells. The LC50 values of the ligand and complexes were found in the range of 9.24-4.12 µg/mL and 5.68-7.94 µg/mL, respectively.

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Section: Molecular Docking Studysupporting

confidence: 89%

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Patel

Dhaduk

Dabhi

et al. 2021

Preprint

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“…Researchers found decreased efficacy in colorectal cancer cell lines and higher efficacy in lung cancer cells of these analogs compared to cisplatin. All complexes induced apoptosis, however, the quinazoline-containing compound exhibited the best response [ 46 ].…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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“…Common mechanism of action of many anticancer compounds is the induction of cancer cell death, mainly apoptosis. It was previously established that some dinuclear Pd(II) complexes induce apoptosis of various cancel cell lines . Also, recent study revealed that dinuclear platinum(II) complexes with 1,5‐naphthyridine as ligand induced apoptotic cell death of CT26 cells .…”

Section: Resultsmentioning

confidence: 98%

“…Section). This can be ascribed to a delocalization of the charge deficiency after cation formation by coordination of Pd(II) ion, throughout all the rings in the molecules …”

Section: Resultsmentioning

confidence: 99%

Potential Antitumor Effect of Newly Synthesized Dinuclear1,5‐Naphthyridine‐Bridging Palladium(II) Complexes

et al. 2020

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Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl}2(μ‐1,5‐nphe)](NO3)2 (L is ethylenediamine (en), (±)‐1,2‐propylenediamine (1,2‐pn), trans‐(±)‐1,2‐diaminocyclohexane (dach), 1,3‐propylenediamine (1,3‐pd), (±)‐1,3‐pentanediamine (1,3‐pnd) and 1,5‐nphe is bridging 1,5‐naphthyridine ligand) were synthesised and spectroscopically characterized. In vitro cytotoxic activity of these complexes was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer cells (LLC1) and melanoma (B16‐F10) as well as human lung adenocarcinoma (A549), mammary carcinoma (MDA‐MB‐468), and colon cancer (HCT 116). The investigated complexes reduced viability of tumor cells in dose dependent manner. Dinuclear Pd(II) complexes act less cytotoxic toward tumor cells, compare to cisplatin, but also have greater selectivity toward mesenchymal stem cells. The potential mechanism of cell death of tumor cells treated with palladium(II) 1,5‐naphthyridine dinuclear complexes is enhanced apoptosis, facilitated by down‐regulation of anti‐apoptotic Bcl‐2 and up‐regulation of pro‐apoptotic Caspase‐3.

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New dinuclear palladium(II) complexes with benzodiazines as bridging ligands: interactions with CT-DNA and BSA, and cytotoxic activity

Cited by 32 publications

References 46 publications

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Potential Antitumor Effect of Newly Synthesized Dinuclear1,5‐Naphthyridine‐Bridging Palladium(II) Complexes

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