New directions in molecular diagnostics and therapy of Vestibular Schwannoma.

Abstract

In recent years a significant progress has been made in the field of molecular background of vestibular schwannoma (VS) emergence and growth. Main genetic and epigenetic aberrations, as well as gene expression changes and specific signaling pathways have been described, that contribute to the development of sporadic VS, and these connected with type II neurofibromatosis (NF2). These findings led to search for potential prognostic markers and biological treatment. In this article we summarize main research directions in the field of molecular diagnostics and biological therapies for VS.