New diterpenoid alkaloids from Delphinium pachycentrum Hemsl

Abstract

Six diterpenoid alkaloids, namely, pachycentine (1), deacetylswinanine A (2), siwanine A (3), tatsiensine (4), deacetyltatsiensine (5), and 6-deoxydeltamine (6), were isolated from a China-specific Delphinium plant (family Ranunculaceae), Delphinium pachycentrum Hemsl. Their structures were established via detailed spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR techniques.Pachycentine (1) is a previously undescribed hetisine-type C 20 -diterpenoid alkaloid, and compounds 5 and 6 were synthetic intermediates newly identified as natural products. In addition, compounds 2-4 were isolated from this species for the first time.The chemotaxonomic significance of all the isolates was summarized. Moreover, the new compound was evaluated for its potential anti-inflammatory effect using LPS-stimulated RAW 264.7 macrophages.

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

“…Among these, only compound 203, obtained from Aconitum, has a hydroxyl group at C-6 [85]. Compounds 204-206 and 211-212 have a hydroxyl group at C-15; notably, only compound 212 shows an α-oriented OH group at C-15 [86]. Compound 210 is the first hetisine-type C20-DA with one hexose substitution, identified as β-glucoside [47].…”