New Enhanced Method for Determination of Trace Sulfamethodxazole Based on the Fluorescence Behaviors of Cyclodextrins in Water Solutions

Wang, Hongling; Si, Xuejing; Wu, Tunhua; Wang, Ping

doi:10.1007/s10895-020-02582-3

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Several methods have been described for SMZ drug estimation like flow injection analysis 4 . selective electroed 5 , spectrophotometric method [6][7][8] , HPLC [9][10][11] , and fluorometry 13 in this manuscript, an accurate, sensitive, and simple of semiautomated flow injection analysis CFIA/MZ technique [14][15][16][17][18] were used to examine the quantitate…”

Section: Introductionmentioning

confidence: 99%

A New Green Approach of CFIA Technique for Direct Assay with a High Throughput of Sulfamethoxazole Drugs Using Condensation Reaction with NQS Agent

Hanooan,

Qassim

2023

Baghdad Sci.J

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A new design of manifold flow injection (FI) coupling with a merging zone technique was studied for sulfamethoxazole determination spectrophotometrically. The semiautomated FI method has many advantages such as being fast, simple, highly accurate, economical with high throughput . The suggested method based on the production of the orange- colored compound of SMZ with (NQS)1,2-Naphthoquinone-4-Sulphonic acid Sodium salt in alkaline media NaOH at λmax 496nm.The linearity range of sulfamethoxazole was 3-100 μg. mL-1, with (LOD) was 0.593 μg. mL-1 and the RSD% is about 1.25 and the recovery is 100.73%. All various physical and chemical parameters that have an effect on the stability and development of the colored product were accurately studied and the designed systems have been completely implemented successfully for sulfamethoxazole quantity estimation in pharmaceutical formulations and biological samples.

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Section: Introductionmentioning

confidence: 99%

A New Green Approach of CFIA Technique for Direct Assay with a High Throughput of Sulfamethoxazole Drugs Using Condensation Reaction with NQS Agent

Hanooan,

Qassim

2023

Baghdad Sci.J

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“…Various analytical techniques have been described for the determination of SMX, such as immunoassay [1,4], Electrochemical [2,5,6] high performance liquid chromatography (HPLC) [3,7] and fluorometry [8,9]. These techniques are expensive and need special training.…”

Section: Introductionmentioning

confidence: 99%

A Novel Spectrophotometric Determination and Kinetic Study of Sulfamethoxazole in Pure and Tablet Formulation using 9-chloroacridine Reagent

Ahmed

Al-Sabha

Al-Hyali

2021

IRJPAC

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A spectrophotometric method has been developed for analysis of Sulfamethoxazole (SMX) in pure and dosage forms. The method is based on the reaction of the SMX with 9-chloroacridine (9-CA) reagent in organic and acidic medium, to produce a yellow product having maximum absorption at 448 nm. Beer’s law was obeyed in the concentration range 1-30 μg.ml-1 with molar absorptivity of 1.63x104 L.mol-1.cm-1 with good detection and quantification limits. Accuracy (Average recovery %) and precision are 98.43% and 0.651, respectively. The proposed method was applied successfully for determination of Sulfamethoxazole in its commercial dosage form as tablet and agree well with the official method. The equilibrium constant and the thermodynamic functions (ΔHo, ΔGº and ΔSº) of the complex formation were estimated. The study revealed that the complex formation could occur spontaneously, the type of interacting forces between SMX and 9-CA are physical is nature and association increases the order of the studied systems. The results of kinetic parameters indicated that, the reaction is pseudo first order with respect to SMX. The rate constant at various temperatures and the thermodynamic functions of activation were determined. Theoretical parameters were calculated by applying the semi-empirical Austin method (AM1). These parameters are helped to suggest reaction mechanism and supporting other results.

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A novel composite of few-layer Nb2CTx and molecularly imprinted polymer with alkenyl ferrocene as cross-linker for ratiometric electrochemical detection of sulfamethoxazole

Yang,

Hu,

Yan

et al. 2025

Microchemical Journal

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New Enhanced Method for Determination of Trace Sulfamethodxazole Based on the Fluorescence Behaviors of Cyclodextrins in Water Solutions

Cited by 4 publications

References 30 publications

A New Green Approach of CFIA Technique for Direct Assay with a High Throughput of Sulfamethoxazole Drugs Using Condensation Reaction with NQS Agent

A New Green Approach of CFIA Technique for Direct Assay with a High Throughput of Sulfamethoxazole Drugs Using Condensation Reaction with NQS Agent

A Novel Spectrophotometric Determination and Kinetic Study of Sulfamethoxazole in Pure and Tablet Formulation using 9-chloroacridine Reagent

A novel composite of few-layer Nb2CTx and molecularly imprinted polymer with alkenyl ferrocene as cross-linker for ratiometric electrochemical detection of sulfamethoxazole

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