New era “soluble triggering receptor expressed on myeloid cells-I” as a marker for early detection of infection in trauma patients

Soud, Dalal; Amin, Olfat Abdelmoniem Ibrahem; Amin, Amal

doi:10.1016/j.egja.2011.07.002

Cited by 6 publications

(18 citation statements)

References 22 publications

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“…Three studies were included in the updated search (15 October 2012) [23-25]. Totally, 11 studies were included for the pooled analysis [9,16-25] (Figure 1). The Cohen Κ statistic for agreement on study inclusion was 0.92.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 1,795 patients were included, comprising 933 patients from ICU in eight studies [9,18-21,23-25], and 862 patients from emergency departments in three studies [16,17,22]. Mean age varied from 31 to 69 years and the proportion of male ranged from 48% to 77%.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies recruited a group of well-matched (age and sex) patients without SIRS (10 patients in Soud et al . 's [16], 37 patients in Barati et al . 's [19], 10 patients in Giamarellos et al .…”

Section: Resultsmentioning

confidence: 99%

“…'s [21], and 15 patients in Rivera et al . 's [20]) as control, and two studies [16,21] included the control patients as well as non- infectious SIRS patients in the non-septic group in a 2 X 2 contingency table when analyzing the diagnostic performance (that is, sensitivity and specificity) of sTREM-1 for sepsis. The prevalence of sepsis across studies ranged from 27% to 73%.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, sTREM-1 may act as a potential biomarker of bacterial infection [14,15]. Recently, several studies have been performed to investigate the role of plasma sTREM-1 in differentiating sepsis from non-infectious SIRS in different settings [9,16-25]. Due to the limited patient sample size recruited in the individual studies, we aimed to conduct a systematic review and meta-analysis to assess the role of plasma sTREM-1 for sepsis diagnosis in adult patients with SIRS.…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis

et al. 2012

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IntroductionEarly diagnosis of sepsis is vital to the clinical course and outcome of septic patients. Recently, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) appears to be a potential marker of infection. The objective of this systematic review and meta-analysis was to evaluate the accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients.MethodsA systematic literature search of PubMed, Embase and Cochrane Central Register of Controlled Trials was performed using specific search terms (up to 15 October 2012). Studies were included if they assessed the accuracy of plasma sTREM-1 for sepsis diagnosis in adult patients with systemic inflammatory response syndrome (SIRS) and provided sufficient information to construct a 2 X 2 contingency table.ResultsEleven studies with a total of 1,795 patients were included. The pooled sensitivity and specificity was 79% (95% confidence interval (CI), 65 to 89) and 80% (95% CI, 69 to 88), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 4.0 (95% CI, 2.4 to 6.9), 0.26 (95% CI, 0.14 to 0.48), and 16 (95% CI, 5 to 46), respectively. The area under the curve of the summary receiver operator characteristic was 0.87 (95% CI, 0.84 to 0.89). Meta-regression analysis suggested that patient sample size and assay method were the main sources of heterogeneity. Publication bias was suggested by an asymmetrical funnel plot (P = 0.02).ConclusionsThe present meta-analysis showed that plasma sTREM-1 had a moderate diagnostic performance in differentiating sepsis from SIRS. Accordingly, plasma sTREM-1 as a single marker was not sufficient for sepsis diagnosis in systemic inflammatory patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis

et al. 2012

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Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis

Qin

Liang

Xia

2021

Infection, Genetics and Evolution

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Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

et al. 2020

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Background: We aim to synthesize the up-to-date studies to investigate the diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis. Results: A total of 19 studies with 2418 patients were finally enrolled in the meta-analysis. The pooled sensitivity was 0.82 (95% CI 0.73 to 0.89), specificity 0.81 (95% CI 0.75 to 0.86), positive likelihood ratio 4.3 (95% CI 3.02 to 6.12), negative likelihood ratio 0.22 (95% CI 0.24 to 0.35), diagnostic odds ratio 20 (95% CI 9 to 41) and AuROC 0.88 (95% CI 0.85 to 0.91). The meta-regression analysis revealed that the sample size, reference standard description, prevalence of sepsis in the trials and consecution of patient recruitment might be the source of heterogeneity. Conclusions: The serum sTREM-1 had a moderate ability in diagnosis in suspected sepsis based on the current studies. However, more large-scale studies were needed to further evaluate the diagnostic accuracy of sTREM-1.

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New era “soluble triggering receptor expressed on myeloid cells-I” as a marker for early detection of infection in trauma patients

Cited by 6 publications

References 22 publications

Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis

Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis

Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis

Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

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