New evidence for deleterious effects of environmental contaminants on the male gamete

Komsky-Elbaz, Alisa; Kalo, Dorit; Roth, Zvi

doi:10.1016/j.anireprosci.2021.106886

Cited by 8 publications

(9 citation statements)

References 151 publications

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“…Alternaria toxins such as alternariol and alternariol 9-methyl ether, derived from filamentous fungi of the Alternaria genus, exhibit endocrine-disrupting potential as estrogen receptor agonists [ 19 ] and may also activate other steroid receptors, such as the androgen and progesterone receptors. Ochratoxins, aflatoxin and patulin are other important mycotoxins produced by Aspergillus species and their endocrine-disrupting activity has been analyzed [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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Endocrine-disrupting compounds are chemicals that alter the normal functioning of the endocrine system of living organisms. They can be natural (N-EDCs) or synthetic compounds (S-EDCs). N-EDCs can belong to different groups, such as phytoestrogens (PEs), including flavonoids, or mycotoxins originating from plants or fungi, and cyanotoxins, derived from bacteria. Humans encounter these substances in their daily lives. The aim of this rapid review (RR) is to provide a fine mapping of N-EDCs and their toxicological effects on human health in terms of various medical conditions or adverse consequences. This work is based on an extensive literature search and follows a rigorous step-by-step approach (search strategy, analysis strategy and data extraction), to select eligible papers published between 2019 and 2023 in the PubMed database, and to define a set of aspects characterizing N-EDCs and the different human target systems. Of the N-EDCs identified in this RR, flavonoids are the most representative class. Male and female reproductive systems were the targets most affected by N-EDCs, followed by the endocrine, nervous, bone and cardiovascular systems. In addition, the perinatal, pubertal and pregnancy periods were found to be particularly susceptible to natural endocrine disruptors. Considering their current daily use, more toxicological research on N-EDCs is required.

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Section: Discussionmentioning

confidence: 99%

“…Detrimental effects can also be observed in the prostate. Following exposure to flavonoids [ 29 ] and mycotoxins such as patulin and nivalenol [ 54 ], a decrease in the relative weight and histopathological changes in prostate tissue were observed.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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“…Approximately 1000 human‐derived chemicals are classified as EDCs, and their effects are often synergistic and cumulative, and may carry over to following generations. Several recent reviews have explored this subject (Graceli et al, 2020; Komsky‐Elbaz et al, 2021; Laws et al, 2021; Repouskou et al, 2021; Roth et al, 2020; Sedha et al, 2021; Weaver et al, 2020; Zhang et al, 2021). In this section, the sources of exposure and the effects on human and animal reproduction of EDCs and certain heavy metals are discussed.…”

Section: Environmental Factors Affecting One Health and Pig Reproductionmentioning

confidence: 99%

“…Polychlorinated biphenyls, brominated flame retardants, polybrominated biphenyls, plastics (bisphenol A) and plasticizers (phthalates) are the most common industrial EDCs (reviewed by Komsky‐Elbaz et al, 2021). Various nutritional supplements and cosmetics are common sources of EDCs, such as phthalates, in our daily lives (Begum et al, 2020).…”

Section: Environmental Factors Affecting One Health and Pig Reproductionmentioning

confidence: 99%

“…The harmful effects of EDCs on sperm count are mediated through effects on testicular development and impaired spermatogenesis (Zhou et al, 2020). Other effects have also been reported, such as disorders of penile development, e.g., hypospadias (Gaspari et al, 2021), but also effects related to sexual behavior, fertilization capacity, and steroidogenesis (reviewed by Komsky‐Elbaz et al, 2021). Phthalates exhibit cytotoxic effects in epididymal and testicular cell cultures of cattle (Yurdakok‐Dikmen et al, 2019) and dogs (Tekin et al, 2020).…”

Section: Environmental Factors Affecting One Health and Pig Reproductionmentioning

confidence: 99%

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One Health challenges for pig reproduction

Peltoniemi

Tanskanen

Kareskoski

2023

Molecular Reproduction Devel

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The current state of the world challenges pig reproduction as an important part of One Health, which involves interrelationships between animal, human and environmental health. The One Health concept underlines a comparative aspect in reproductive physiology and disease occurrence, bridging knowledge from one species to another. Seasonal changes in the environment affect pig reproduction and climate change may further strengthen those effects. Endocrine‐disrupting chemicals (EDCs), and specifically phthalates and heavy metals, interfere with endocrine function, and thereby sexual behavior, fertilization capacity and steroidogenesis. Reproductive infections and extended semen storage are important indications for antimicrobial use. Innovative solutions are needed to explore alternatives to antimicrobials. Efforts to ensure reproductive efficiency have prolonged farrowing as litter size has doubled over the past three decades, compromising immune transfer and welfare. Physiological, metabolic and programming related events around parturition are key areas for future One Health research in pig reproduction. In conclusion, climate change challenges reproductive management and breeding. More resilient pigs that can tolerate harsh environment but maintain high reproductive performance are needed. EDCs continue to grow as an environmental challenge for reproductive management and alternatives to antibiotics will be required.

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Atrazine and its degradation products in drinking water source and supply: Risk assessment for environmental and human health in Campinas, Brazil

et al. 2023

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New evidence for deleterious effects of environmental contaminants on the male gamete

Cited by 8 publications

References 151 publications

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

One Health challenges for pig reproduction

Atrazine and its degradation products in drinking water source and supply: Risk assessment for environmental and human health in Campinas, Brazil

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