New findings explaining the mode of action in prevention of facial clefting and first clinical experience

The time of palatal fusion in mice: a factor of strain susceptibility to teratogens

“…Our first experience with this model follows the basic experimental work of Schubert (1982) and Schubert et al (1990). The positive results of prevention of neural tube defects which were first noted in 1981 (Smithells et al, 1989;Milunsky et al, 1989;MRC-Group, 1991;Czeizel et al, 1992) has stimulated the clinical application of preventive measures in mothers at risk as well as further experimental studies in preventive measures.…”

“…The positive results of prevention of neural tube defects which were first noted in 1981 (Smithells et al, 1989;Milunsky et al, 1989;MRC-Group, 1991;Czeizel et al, 1992) has stimulated the clinical application of preventive measures in mothers at risk as well as further experimental studies in preventive measures. Current studies are directed towards the preventive possibilities of vitamin application following the induction of different types of cleft deformity using different teratogens.…”

Influence of season on prevalence of cleft lip and palate

“…As a result of their established protective effect, vitamins of the B-group are a well-tried component of preventive measures 21,22 . Milk, and especially, lettuce and vegetables in the first place meet the demand for vitamins.…”

Vitamin B-Complex Application Promotes Secondary Palate Development in a Palate Organ Model of the A/WySnJ Mouse

“…15,26 In contrast to neural tube defects, there is no international consensus regarding preventative measures or prophylactic vitamin substitutions for pregnant women in these cleft-related families. However, it has been shown that consistent dietary vitamin supplementation, including folic acid, can decrease the frequency of cleft appearance in these families.…”

“…14 The nonspecific vitamin B supplementation of women with some form of increased risk for clefting during the entire period from embryogenesis to fetal development (6 to 16 days post conceptionem) has shown a clearly effective protection in up to 70%. 15 The aim of this study was to analyze the direct influence of the vitamin B-complex (Polybion N, Merck GmbH, Darmstadt, Germany) on palatal shelf development in a genetically cleft-related animal model. Therefore, an established and reproducible in vitro palatal organ model [16][17][18] was chosen to eliminate any maternal influence.…”