“…38 Moreover, absolute peripheral blood flow is reduced in human hypertension 39 because of high blood viscosity 40 and abnormal erythrocyte rheology, such as reduced membrane fluidity, 41 and an elevated erythrocyte free Ca 2+ concentration. 42 This line of evidence implies that circulating erythrocytes of hypertensive patients experience persistent inflammatory damage and shear stress, which impairs erythrocyte filterability by signal transduction involving intracellular Ca 2+ .…”