New flavan and unusual chalcone glycosides from Drypetes parvifolia

Nenkep, Viviane N.; Shirri, Jovita Chi; Van-Dufat, Hanh Trinh; Sipepnou, Falindor; Vérité, Philippe; Seguin, Elisabeth; Tillequin, François; Wandji, Jean

doi:10.1016/j.cclet.2008.04.048

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…The sugar moiety in compound 1 was determined to be glucose based on the comparison of the 1 H and 13 C NMR data with those of glucose reported in the literature (Nenkeo et al, 2008). Complete 1 H and 13 C NMR chemical shift assignments of 1 and its HSQC spectral data are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities

Ata

Tan

Matochko

et al. 2011

Phytochemistry Letters

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Section: Resultsmentioning

confidence: 99%

Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities

Ata

Tan

Matochko

et al. 2011

Phytochemistry Letters

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“…Furthermore, smilaside C (123) was isolated from the DCM extract of the roots of D. hoaensis (Wittayalai et al, 2014), and the ethanolic extract of the stem of D. littoralis gave lariciresinol (124) The latter was previously reported from the EtOH extract of the stem of D. littoralis (Lin et al, 2001). Furthermore, the extract of the stem bark of D. parvifolia delivered a flavan glycoside, 7-hydroxy-5-O-β-D-glucopyranosideflavan (129), and an unusual chalcone glycoside, (Z)-4´,6´-dihydroxy-2´-O-β-D-glucopyranosidechalcone (130) (Nenkep et al, 2008), while the EtOH extract of fresh leaves of D. roxburghii yielded gallocatechin (131) (Chopra et al, 1970b). In addition, a biflavonoid, namely putraflavone or 7,4′'′-dimethyl amentoflavone (132), was isolated from the acidic fraction of the alcoholic extract of the leaves of this plant (Garg and Mitra, 1971b).…”

Section: Phenylpropanoids and Phenylethanoidmentioning

confidence: 94%

“…chevalieri (Wansi et al, 2006(Wansi et al, , 2007, D. gerrardii (Ng´ang´a et al, 2008(Ng´ang´a et al, , 2012, D. parvifolia (Nenkep et al, 2008), D. tessmanniana (Dongfack et al, 2008), D. paxii (Chiozem et al, 2009), D.…”

Section: Triterpenoidsmentioning

confidence: 98%

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Phytochemistry and pharmacology of the genus Drypetes: A review

Wansi

Wandji

Sewald

et al. 2016

Journal of Ethnopharmacology

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Plants of this genus have offered bioactive samples, both from crude extracts and pure compounds, partly validating their effectivity in traditional medicine. However, most of the available scientific literatures lacks information on relevant doses, duration of the treatment, storage conditions and positive controls for examining bioefficacy of extract and its active compounds. Additional toxicological studies on the species used in local pharmacopeia are urgently needed to guarantee safe application due to high toxicity of some crude extracts. Interestingly, this review also reports 10 pimarane dinorditerpenoids structures with the aromatic ring C, isolated from the species collected in Asia Drypetes littoralis (Taiwan), D. perreticulata (China), and in Africa D. gerrardii (Kenya), D. gossweileri (Cameroon). These compounds might turn out to be good candidates for chemotaxonomic markers of the genus.

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“…Earlier phytochemical studies on some Drypetes plant species including D. parrifolia, D. laciniata, D. inaequalis, D. armoracia, D. gossweileri, D. molunduana, D. roxburghii have yielded flavonoids, chalcone glycosides, saponins, tripterpenoids, phenolics, alkaloids, etc. (Nenkep et al, 2008;Fannang et al, 2011;Awanchiri et al, 2009;Wandji et al, 2003;Wandji et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory, cytotoxic and antioxidant effects of methanolic extracts of <i>Drypetes Sepiaria</i> (Euphorbiaceae)

Gadamsetty

Maru

Tyagi

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The aim of this study was to investigate in vitro antioxidant, anti-inflammatory and cytotoxic activities of the petroleum ether, ethyl acetate, methanol and aqueous extracts obtained from leaves of Drypetes sepiaria (Euphorbiaceae). Total phenolic and flavonoid contents of these crude extracts were determined as gallic acid and quercetin equivalents, respectively. In in vitro antioxidant method, methanol extract exhibited higher free radical scavenging activity compared to standard compound, ascorbic acid with IC 50 of 95.43µg/ml (DPPH) and 67.05µg/ml (ABTS). Methanol extract was able to inhibit inflammation by in vitro about 85-90% (HRBC stabilization method) and in vivo about 40-45% (Paw oedema method) anti-inflammatory assays compared to standard produced 50.04% at 6h period. In cytotoxicity assay (MTT assay) methanolic extract exhibited IC 50 of 10µg/ml. In apoptosis (flow cytometric assay), the control group showed normal caspase 3 activity in the SiHa cells which was 0.24%, and increased up to 40% after treatment.

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New flavan and unusual chalcone glycosides from Drypetes parvifolia

Cited by 10 publications

References 10 publications

Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities

Chemical constituents of Drypetes gossweileri and their enzyme inhibitory and anti-fungal activities

Phytochemistry and pharmacology of the genus Drypetes: A review

Anti-inflammatory, cytotoxic and antioxidant effects of methanolic extracts of <i>Drypetes Sepiaria</i> (Euphorbiaceae)

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