New Fluorometric Micromethod for the Determination of Reserpine.

Semiautomated Fluorometric Determination of Rauwolfia Alkaloids

“…The specific p-toluenesulfonic acid fluorometric method for reserpine of Jakovljevic et ul. (4), which is claimed to be sensitive, did not give reproducible results with rauwolfia alkaloids because of interference from the decomposition products. However, the author's previously reported (6) nitrous acid fluorescent method for reserpine, with modifications, was satisfactory for the automated determination.…”

“…The analytical procedures published for the quantitative determination of rauwolfia alkaloids are either colorimetric (2, 3) or fluorometric (4,5). The colorimetric procedures are not sensitive and specific for the determination of low concentration level drugs.…”

Excretion and metabolism of reserpine In renal failure

“…The specific activity of this solution was established by counting an aliquot and measuring reserpine fluorometrically in the remainder. 3 Knowing the specific activity of the final solution and the amount (2 mg.) of cold reserpine added to the plasma or urine, it was possible to calculate the amount of radioactive reserpine in the sampies taken from the patient. Feces sampies were lyophilized, and 50 mg. aliquots of the dried powder were incinerated; their radioactivity was determined.…”

Enhanced Absorption and Dissolution of Reserpine from Reserpine-Polyvinylpyrrolidone Coprecipitates

“…(16) for the determination of reserpine in pure aqueous media and pharmaceutical 1 Supplied by Ciba Pharmaceutical Co., Summit. NJ 07901 * Plasdone-C (K-30); supplied by the General Aniline and Film 3 Eastman Organic Chemicals, Rochester, N. Y.…”