New frontiers for cartilage repair, joint preservation and prevention

Brittberg, Mats

doi:10.1016/j.jcjp.2022.100060

Cited by 13 publications

(4 citation statements)

References 104 publications

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“…Cartilage restoration techniques encompass autologous surface repair techniques, cell transplantation, and osteochondral graft transplantation, all of which strive to mend or substitute damaged cartilage. [10]. They offer solutions for managing cartilage defects and promoting cartilage regeneration in patients with knee osteoarthritis [11].…”

Section: Surgical Techniques For Joint Preservationmentioning

confidence: 99%

Orthopedic Joint Preservation: A Comprehensive Review

Obeid

2024

ASS

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This comprehensive review article delves into the intricate realm of orthopedic joint preservation with a focus on surgical techniques, innovative treatments, rehabilitation protocols, and long-term outcomes. Within the orthopedic landscape, joint preservation plays a crucial role in enhancing patient quality of life and functional outcomes. The article delivers a detailed exploration of various surgical techniques utilized for joint preservation, encompassing arthroscopy, cartilage repair, osteotomy, and ligament reconstruction. By scrutinizing the indications, outcomes, and potential complications associated with these procedures, the article aids in providing a comprehensive understanding for practitioners. Moreover, it delves into the realm of cutting-edge treatments such as regenerative medicine, stem cell therapy, and biologic agents, shedding light on their significant role in promoting joint preservation and fostering tissue healing. Rehabilitation protocols for joint preservation are also thoroughly evaluated, underlining the pivotal role of early mobilization, tailored physical therapy regimens, and patient education in fostering optimal outcomes while averting potential complications. Through an assessment of long-term outcomes post joint preservation interventions including functional improvements, pain management, and patient contentment, the article endeavors to gauge the efficacy and longevity of these interventions. By offering a nuanced overview of the current state of joint preservation in orthopedics, the article extends valuable insights to orthopedic surgeons, researchers, and healthcare professionals actively engaged in managing joint disorders.

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Section: Surgical Techniques For Joint Preservationmentioning

confidence: 99%

Orthopedic Joint Preservation: A Comprehensive Review

Obeid

2024

ASS

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“…Many chemokines and growth factors were also utilized to attract intrinsic MSCs to participate in cartilage regeneration. 56,57 Despite this, their application might be limited by unexpected side effects. 19 3.6.…”

Section: Apt19s Effectively Promoted the Migration And Recruitment Of...mentioning

confidence: 99%

Functional injectable hydrogel with spatiotemporal sequential release for recruitment of endogenous stem cells and in situ cartilage regeneration

Dai

Liu

et al. 2023

J. Mater. Chem. B

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“…Natural healing of the cartilage is little to non-existent, especially if the damage is severe and cell maturity has been achieved. The main reason for this is the poor vascularisation and innervation of cartilage tissue, making nutrient transport to the cartilage cells very limited thus slowing down metabolic processes [2,3].…”

Section: Introductionmentioning

confidence: 99%

Migration and remodeling in cartilage replacement materials – an in‐vitro bioreactor study

Ortiz

Dursun

Topol

et al. 2023

Proc Appl Math and Mech

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This article presents a bioreactor study that investigates the influence of mechanical stimulation on cell migration in a cartilage replacement material. The bioreactor has been designed to carry out dynamic stimulation of cell-seeded scaffolds, and it consists of a loading mechanism, a force-measuring device, and a biocompatible chamber. The stimulation of the samples was carried out inside a bioreactor chamber, which simulates physiological conditions that are found in vivo. Cell migration was determined using two collagen scaffolds, a part that mimics native tissue and a second cell-free implant. The two parts were positioned in direct contact with each other, and the samples were then subjected to cyclic compression loading for a two-week time frame. We determined the cell viability, the number of migrated cells, and the migration depth into the initially cell-free part of the specimen. The results from the dynamic loading were compared with an unloaded control sample. The cell migration effect was determined for different collagen concentrations, which allowed us to observe the relationship between the collagen content and cellular activity. The present results were compared to results from the literature.

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New frontiers for cartilage repair, joint preservation and prevention

Cited by 13 publications

References 104 publications

Orthopedic Joint Preservation: A Comprehensive Review

Orthopedic Joint Preservation: A Comprehensive Review

Functional injectable hydrogel with spatiotemporal sequential release for recruitment of endogenous stem cells and in situ cartilage regeneration

Migration and remodeling in cartilage replacement materials – an in‐vitro bioreactor study

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