2019
DOI: 10.5101/nbe.v11i1.p84-90
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New Gemcitabine Derivatives as Potent in vitro α-Glucosidase Inhibitors

Abstract: In this work, new heterocyclic compounds 1,2,3-triazoline derivatives starting from gemcitabine were synthesized. At first, gemcitabine was converted to 2-azido gemcitabine (G) through the reaction of gemcitabine with sodium azide. 1,2,3-Triazolines were prepared from the reaction of 2-azido gemcitabine with some unsaturated compounds such as malic anhydride, cinamic acid and acryl amide by click reaction. The products were identified by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magneti… Show more

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Cited by 4 publications
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