New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women

Poorhosseini, Seyed Mohammad; Hashemi, Mohammad; Olyaei, Nasrin Alipour; Izadi, Azimeh; Moslemi, Elham; Ravesh, Zeinab; Hashemi‐Gorji, Feyzollah; Kheiri, Hamid Reza; Yassaee, Vahid Reza

doi:10.7314/apjcp.2016.17.s3.155

Cited by 11 publications

(4 citation statements)

References 29 publications

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“…LSP1, which is mainly expressed in lymphocytes [27], neutrophils [28], macrophages [29] and endothelium [30], has been reported to be correlated with several kinds of cancers, such as breast cancer [31], lymphomas [8], pancreatic cancer [9] and dermatofibroma [6]. Polymorphisms of LSP1 are associated with high risk of breast cancer in women who have an existing mutation of the BRCA1 gene [32]. More importantly, in rat HCC, the LSP1 gene was reported to be a tumor suppressor, existing at high CNV, which can regulate hepatocellular proliferation and migration in rat via inhibiting the MAPK/ERK pathway [10,11].…”

Section: Discussionmentioning

confidence: 99%

Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation

et al. 2016

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Lymphocyte‐specific protein 1 ( LSP 1) has been reported to regulate cell biology in several human cancers including lymphoma and breast cancer. However, the functions of LSP 1 in human hepatocellular carcinoma ( HCC ) are still unknown. In this study, we found that LSP 1 expression was downregulated in HCC tissues and cell lines, and lower LSP 1 expression was correlated with poor clinicopathological features including large tumor size, high Edmondson–Steiner grading and advanced tumor–node–metastasis ( TNM ) stage. Additionally, we demonstrated that patients with high LSP 1 expression had significantly better overall survival and disease‐free survival. Moreover, LSP 1 was found to be an independent factor for predicting the prognosis of HCC patients. In vitro and in vivo assays showed that overexpressing LSP 1 inhibited HCC growth by inducing both apoptosis and growth arrest. Mechanistically, we found that expression of phosphorylated extracellular regulated protein kinases 1 and 2 ( ERK 1/2) was downregulated after LSP 1 overexpression, indicating LSP 1 could suppress HCC growth by inhibiting the ERK pathway in HCC cells. Taken together, these results indicate that LSP 1 may serve as a prognostic marker and a potential therapeutic target in human HCC .

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Section: Discussionmentioning

confidence: 99%

Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation

et al. 2016

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“… 2 Due to the growing side effects of conventional chemotherapeutic approaches, there is more attention to finding alternative ways for improving the immune system to target the advanced stages of tumors. 3 Several natural herbal components have been conventionally applied to treat various disorders for a long time. Current investigations have been focused on natural extracts of fungi, particularly those with low cellular toxicity for normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

et al. 2022

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“…There are several ways to treat breast cancer, depending on its type and stage. Some treatments are called local therapies, meaning they treat the tumor without affecting the rest of the body [5]. Types of local therapy used for breast cancer include: Surgery and therapy, these treatments are more likely to be useful for ear-lier stage (less advanced) cancers, although they might also be used in some other conditions.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of PEGylated Iron Oxide-Gold Nanoparticles for Delivery of Sulforaphane and Curcumin

et al. 2017

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Natural products have been used for the treatment of various diseases such as cancer. Curcumin (CUR) and sulforaphane (SF) have anti-cancer effects, but their application is restricted because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an advanced delivery of SF and CUR with PEGylated gold coated FeO magnetic nanoparticles (PEGylated FeO@Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs. The structure of the synthesized nanocarrieris evaluated by, transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR). The results revealed that the size of NPs was 20 nm. They were mono-dispersed in water, with high drug-loading capacity and stability. CUR and SF were encapsulated into NPs with loading capacity of 16.32±0.023% and 15.74±0.015% and entrapment efficiency of 74.57±0.14% and 72.20±0.18% respectively. The in-vitro study of SF and CUR loaded PEGylated FeO@Au NPs on human breast adenocarcinoma cell line (SK-BR-3) confirmed that cytotoxicity of SF and CUR can enhance when they are loaded on PEGylated FeO@Au NPs in comparison to Free SF and void CUR. The results of flow cytometry and real-time PCR shown that nano-carriers can increase therapeutic effects of SF and CUR by apoptosis and necrosis induction as well as inhibiting of migration in SK-BR-3 cell line.

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New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women

Cited by 11 publications

References 29 publications

Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation

Retracted: Lymphocyte‐specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation

Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

Preparation and Characterization of PEGylated Iron Oxide-Gold Nanoparticles for Delivery of Sulforaphane and Curcumin

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