New generation natural face cream formulation: development and in vitro evaluation

Abstract

Aim; In developing societies, acne, blemish, wrinkle formation in the face area and the deteriorating structure of the skin require constant care. Acne and scars are observed due to increased sebum formation and microorganisms. In addition, dark spots on the skin develop due to excess melanin. We aimed to develop a face cream formula containing Rosa damascena Mill. and Avena Sativa L (oat). Method; Cream formulations were prepared using three components (surfactant, oil phase, water phase) by emulsification method. HLB values of the formulations were calculated based on oil phase concentration. Reliability of the components used in the formulation was calculated using MoS values PODsys / (SED*cons.%). It was calculated based on the resistance to shear with a rotational viscometer. Physicochemical properties were tested under different climate conditions for 3 months. Total bacteria and fungi analyses were reported as CFU/g for Staphylococcus aureus, aerobic mesophilic (bacteria, yeast mold), Escherichia coli, Pseudomonas aeroginosa, Candida albicans using pour plate method. Results; The result of organoleptic control of cream formulations showed that nine formulations formed homogeneous and single phase stable creams. The tenth formulation showed phase separation observed in creams due to wrong emulsifier selection. According to the spreadability and fluidity properties, viscosity values in FC-F-7 formulation varied between 1944.5 ± 342.3 cP and 40953.0 ± 1787.0 cP. These results showed that cetyl alcohol increased viscosity compared to beeswax and paraffin wax. As a result of the search for a cream formulation with suitable physicochemical properties for face area, FC-F-7 formulation was developed. Conclusion; It has been found that fatty esters have an effect on physical properties such as rheology and spreadability when developing cream formulations. In cream formulations to be developed for the face area, the design and development of formulations with natural ingredients that have proven their reliability and stability have been carried out.