New horizons in specific hormone proteolysis

Triebel, Jakob; Robles, Juan Pablo; Zamora, Magdalena; Clapp, Carmen; Bertsch, Thomas

doi:10.1016/j.tem.2022.03.004

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…While our five kinases have been implicated in traditional AD pathology (such as tau phosphorylation, amyloid processing), there is emerging evidence for a role in mediating key metabolic pathways. In fact, the three shared pathways in the underrepresented kinases converge on classical pathways mediating metabolic pathways: FoxO, Prolactin, and Cellular senescence (41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimer’s Disease

Henkel

Joyce

Shedroff

et al. 2022

Preprint

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Neurons and astrocytes derived from Alzheimers Disease (AD) patient induced pluripotent stem cells are an evolving technology used to study the pathogenesis and etiology of AD. As the utility of mouse models of AD are increasingly coming into questions, using iPSC technology may offer an opportunity to study this disease with human substrates. Herein, we using a hypothesis generating platform, the PamGene12 Kinome Array, to identify core protein kinases in neurons and astrocytes derived from familial AD patient iPSCs. We identified five core protein kinases in these cells and examined the pathways in which they are enriched. Importantly, we complement our findings using an in-silico approach with postmortem AD brain datasets. While these protein kinases have been conceptualized in the context of traditional AD pathology, they have not been explored in the context of aberrant signaling in the pathophysiology of the disease.

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Section: Discussionmentioning

confidence: 99%

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimer’s Disease

Henkel

Joyce

Shedroff

et al. 2022

Preprint

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“…These DEGs were signi cantly enriched in the regulation of transcription by RNA polymerase II, proteolysis, cytoplasm, nucleus, metal ion binding, and ATP binding. Proteolysis plays an essential role in crustaceans, such as providing amino acids to the body, assisting in the production of active proteins, regulating physiological and cellular processes, and preventing the accumulation of unnecessary or abnormal proteins in cells (Triebel et al 2022). Metal ion binding is involved in transporting oxygen and improving the immunity of the body (Shrivastava et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Fan

Knepper

et al. 2022

Preprint

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Temperature is an essential factor affecting the viability of crustaceans, and high temperature can cause damage or even death. The oriental river prawn, Macrobrachium nipponense, is an important economic aquaculture species in China, Japan, and Vietnam. To identify the transcriptomic, histological, and biochemical response of M. nipponense and reveal their adaptation mechanisms, the prawns were placed at 25 ℃, 30 ℃, and 35 ℃ for 24 h. The histological damages in the gills and hepatopancreas of M. nipponense were found under acute heat stress. Additionally, acute heat stress enhanced the digestive, metabolic, and antioxidative capacity of M. nipponense by biochemical analysis. The total RNA of hepatopancreas and gills were isolated and sequenced using the RNA-Seq method. After filtration, assembly, and aggregation, a total of 131690 unigenes were identified. Gene ontology (GO) analysis revealed that differentially expressed genes (DEGs) were significantly involved in the regulation of transcription by RNA polymerase II, proteolysis, nucleus, cytoplasm, nucleus, and ATP binding. In the hepatopancreas, several pathways were significantly enriched in the treatment groups, including neuroactive ligand-receptor interaction, thyroid hormone synthesis, and ECM-receptor interaction. And in the gills, cGMP-PKG signaling pathway, ribosome, and calcium signaling pathway, were enriched. The transcriptomic analysis provided insights into the thermoregulation and molecular mechanisms of M. nipponense in response to acute heat stress.

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“…The cleavage sites in PRL through which vasoinhibin is generated are conserved in vertebrates (47, 67, 73) and high affinity cleavages sites evolved, most likely as a gain of function under positive selection, as a unique feature of higher primates (74). The cleavage of PRL to generate vasoinhibin occurs in the wider context of a hormone-metabolism junction, through which specifically cleaved hormones regulate essential functions to maintain homeostasis at the organismal, tissue, or organ levels (75,76). The PRL/vasoinhibin axis contributes to maintaining corneal avascularity (66), restricts retinal vasculature (65), and is disrupted in retinopathy of prematurity (77, 78).…”

Section: The Prl/vasoinhibin Axis Controls Ocular Angiogenesis and Va...mentioning

confidence: 99%

Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited

Triebel

Bertsch²,

Clapp³

2022

Front. Endocrinol.

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Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes for visual loss in adults. Nearly half of the world’s population with diabetes has some degree of DR, and DME is a major cause of visual impairment in these patients. Severe vision loss occurs because of tractional retinal detachment due to retinal neovascularization, but the most common cause of moderate vision loss occurs in DME where excessive vascular permeability leads to the exudation and accumulation of extracellular fluid and proteins in the macula. Metabolic control stands as an effective mean for controlling retinal vascular alterations in some but not all patients with diabetes, and the search of other modifiable factors affecting the risk for diabetic microvascular complications is warranted. Prolactin (PRL) and its proteolytic fragment, vasoinhibin, have emerged as endogenous regulators of retinal blood vessels. PRL acquires antiangiogenic and anti-vasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, which helps restrict the vascularization of ocular organs and, upon disruption, promotes retinal vascular alterations characteristic of DR and DME. Evidence is linking PRL (and other pituitary hormones) and vasoinhibin to DR and recent preclinical and clinical evidence supports their translation into novel therapeutic approaches.

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New horizons in specific hormone proteolysis

Cited by 6 publications

References 37 publications

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimer’s Disease

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimer’s Disease

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited

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