New ideas on the ALS Functional Rating Scale

Swash, Michael

doi:10.1136/jnnp-2016-315116

Cited by 4 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, nine patients fulfilled the criteria for definite ALS, 19 patients met the criteria for probable ALS, and none of them fulfilled the requirements for possible ALS. They were scored using the revised ALS Functional Rating scale (ALSFRS-R) which denotes 12 items (each of 5 scores from 0 to 4) [14]. Key muscles from the upper and lower extremities were evaluated using the Medical Research Council (MRC) scale against the examiner's resistance and grading the patient's strength on a 0 to 5 scale accordingly [15].…”

Section: Methodsmentioning

confidence: 99%

Motor unit number estimation versus compound muscle action potential in the evaluation of motor unit loss in amyotrophic lateral sclerosis

Ibrahem

Al-Mahdawi

Hamdan

2021

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Introduction Motor neuron loss is the primary pathologic feature of amyotrophic lateral sclerosis (ALS). An estimate of the number of surviving motor units (MUs) represents a direct measure of the disease state in ALS. The objective of the study is to compare MU number estimation (MUNE) using the multipoint stimulation method (MPS) and compound muscle action potentials (CMAP) amplitude in patients with ALS. Methods Twenty-eight patients with ALS with a disease duration of 3–48 months were studied. Nerve conduction study of the median, ulnar, tibial, common peroneal, and sural nerves were done. Besides, electromyography (EMG) of cranio-bulbar, cervical, thoracic and lumbosacral muscles, and MPS-MUNE. Results MUNE is decreased in patients with ALS. MUNE was positively correlated with CMAP amplitude, medical research council (MRC) scale, and ALS functional rating scale (ALS-FRS). On the contrary, MUNE was negatively correlated with MUAP duration. Case detection by the MUNE methods was high as compared to that of CMAP amplitude. Conclusions MUNE is highly specific and more sensitive than CMAP amplitude in detecting the neurophysiologic abnormalities in patients with ALS. Case detection by MUNE is three times more than CMAP amplitudes. The rate of decline of motor units using the MPS-MUNE is more sensitive than the MRC score and ALSFRS-R when expressed as the percentage change from baseline.

show abstract

Section: Methodsmentioning

confidence: 99%

Motor unit number estimation versus compound muscle action potential in the evaluation of motor unit loss in amyotrophic lateral sclerosis

Ibrahem

Al-Mahdawi

Hamdan

2021

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

show abstract

Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice

Güneş

Şırın

Sahin

et al. 2021

Neuroscience Letters

View full text Add to dashboard Cite

Split limb phenomenon in amyotrophic lateral sclerosis: electrophysiologic study

Abdul-wahab,

Al-Mahdawi

2023

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background Amyotrophic lateral sclerosis (ALS) is a degenerative disease that affects the upper and lower motor neurons. The onset of the disease is frequently focal, usually involving the distal segments of the extremities. A dissociated pattern of muscle atrophy is commonly found in the hands and feet. This study aims to investigate the presence (if any) of split indices in ALS patients and to correlate these indices with confounding factors. A total of 48 people were studied. The control group consists of 24 ALS patients and another 24 age- and gender-matched patients. To assess functional status and muscle strength, the ALS functional rating scale (ALSFRS) and the Medical Research Council (MRC) were used, respectively. Sensory and motor nerve conduction, as well as compound muscle action potential (CMAP) amplitude, were recorded from the muscles of the upper and lower limbs. The electromyographic (EMG) activity of 20 motor unit action potentials (MUAPs) from four different areas was also studied. Results Distal CMAP amplitude was reduced in all tested muscles (especially noticed when comparing the reciprocal muscles). In ALS patients, the split foot index (SFI) is significantly higher, while the split elbow index (SEI) is significantly lower. The split foot index (SFI) was found to be negatively related to disease duration, but positively related to ALSFRS scores. The CMAP amplitude was found to be positively related to the MRC score. Conclusion Ankle dorsiflexion muscles are more involved (dissociated) than plantar flexor muscles, and elbow flexors are more involved than extensors. SFI correlates significantly with disease duration and ALSFRS scores.

show abstract

New ideas on the ALS Functional Rating Scale

Cited by 4 publications

References 9 publications

Motor unit number estimation versus compound muscle action potential in the evaluation of motor unit loss in amyotrophic lateral sclerosis

Motor unit number estimation versus compound muscle action potential in the evaluation of motor unit loss in amyotrophic lateral sclerosis

Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice

Split limb phenomenon in amyotrophic lateral sclerosis: electrophysiologic study

Contact Info

Product

Resources

About