New Imaging Technology for Simultaneous Multiwavelength-UWF Fundus Fluorescein Angiography and Indocyanine Green Angiography With Navigated Central and Peripheral SS-OCT

Abstract

Objective: Our aim was to assess central and peripheral retinal and choroidal diseases using novel simultaneous multiwavelength-ultra-widefield (MW-UWF) fundus fluorescein angiography (FFA)/indocyanine green angiography (ICGA) with navigated central and peripheral swept-source optical coherence tomography (SS-OCT) technology. Methods: Retrospective evaluation was carried out of 30 consecutive patients (60 eyes) who underwent UWF red/green (RG), infrared (IR), FFA and ICGA with simultaneous navigated SS-OCT using Optos Silverstone (Optos PLC). Angiographic retinal and choroidal findings in vascular pathologies and their relationship with the vitreoretinal interface (VRI) were assessed. Results: Simultaneous FFA with navigated SSOCT was performed in all patients and simultaneous FFA-ICGA with SS-OCT in 18 eyes (30%). Cross-sectional central and peripheral changes in the retina, choroid, and VRI corresponding with angiographic findings in several diseases were imaged. Conclusion: First-in-human study of a new technology providing UWF RG/FFA/ICGA with simultaneous navigated central and peripheral SS-OCT can guide clinical management and provide new insights and understanding of central and peripheral retinal and choroidal disease. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:xx–xx.]

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

“…However, the subsequent advent of new imaging technologies, such as simultaneous UWF imaging and navigated central and peripheral SS-OCT has opened new avenues in vitreoretinal diagnostics. [ 58 ] These new imaging techniques offer a more holistic view of the retina and enable clinicians to assess areas that were previously inaccessible, potentially leading to increased understanding of SO, its emulsification and related adverse events. [ 38 58 59 ]…”

“…[ 58 ] These new imaging techniques offer a more holistic view of the retina and enable clinicians to assess areas that were previously inaccessible, potentially leading to increased understanding of SO, its emulsification and related adverse events. [ 38 58 59 ]…”

“…Most of these devices, such as OptosSilverstone (Optos PLC, Dunfermline, Scotland, United Kingdom), operate based on the principle of scanning laser ophthalmoscopy and combine several UWF imaging methods, including red–green fundus imaging, fundus autofluorescence, fundus fluorescein and indocyanine green angiography and simultaneous navigated central and peripheral SS-OCT.[ 58 ] This multiwavelength and multimodal approach provides improved assessment and a better understanding of vitreous, VRI, retinal, and choroidal diseases, not only within the posterior pole but also of the peripheral retina. [ 58 ]…”

“…[ 85 86 ] The use of new UWF devices may therefore play a pivotal role in identifying SO emulsification and its related complications, leading to new insights into how SO affects the peripheral retina. [ 58 ]…”

The role of ultra-widefield imaging with navigated central and peripheral cross-sectional and three-dimensional swept source optical coherence tomography in ophthalmology: Clinical applications

“…[ 1 2 ] Recent developments in ultra-widefield (UWF) angiographic imaging with simultaneous navigated central and peripheral optical coherence tomography (OCT) have led to a better understanding of vitreoretinal and choroidal diseases. [ 3 ]…”